Unique prognostic factors in acral lentiginous melanoma

Michael E. Egger, Kelly M. McMasters, Glenda G. Callender, Amy R. Quillo, Robert C.G. Martin, Arnold J. Stromberg, Charles R. Scoggins

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Background: This study was performed to identify clinicopathologic factors associated with survival in acral lentiginous melanoma. Methods: A post hoc analysis of a prospective clinical trial and local database was performed in all patients with acral lentiginous melanomas. Multivariate analyses of factors associated with a tumor-positive sentinel lymph node (SLN) biopsy, disease-free survival (DFS), overall survival (OS), and local and in-transit recurrence-free survival (LITRFS) were performed. Kaplan-Meier survival analyses were performed. Results: Eighty-five patients were identified. Age younger than 59 years and Breslow thickness (BT) of 2.0 mm or greater were independent risk factors for a positive SLN. SLN status was the only independent risk factor for DFS and LITRFS on multivariate analysis. A BT of 2.0 mm or greater was the only independent risk factor for OS. SLN status distinguished differences in DFS, OS, and LITRFS on Kaplan-Meier analysis. Conclusions: SLN status is the dominant factor for recurrence and survival in acral lentiginous melanoma. BT and ulceration are less important in this histologic subtype.

Original languageEnglish
Pages (from-to)874-880
Number of pages7
JournalAmerican Journal of Surgery
Volume204
Issue number6
DOIs
StatePublished - Dec 2012

Keywords

  • Acral lentiginous melanoma
  • Acral melanoma
  • Extremity melanoma
  • Melanoma histology
  • Sentinel lymph node biopsy

ASJC Scopus subject areas

  • Surgery

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