University-based outbreaks of meningococcal disease caused by serogroup B, United States, 2013-2018

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61 Scopus citations


We reviewed university-based outbreaks of meningococcal disease caused by serogroup B and vaccination responses in the United States in the years following serogroup B meningococcal (MenB) vaccine availability. Ten university-based outbreaks occurred in 7 states during 2013-2018, causing a total of 39 cases and 2 deaths. Outbreaks occurred at universities with 3,600-35,000 undergraduates. Outbreak case counts ranged from 2 to 9 cases; outbreak duration ranged from 0 to 376 days. All 10 universities implemented MenB vaccination: 3 primarily used MenB-FHbp and 7 used MenB-4C. Estimated first-dose vaccination coverage ranged from 14% to 98%. In 5 outbreaks, additional cases occurred 6-259 days following MenB vaccination initiation. Although it is difficult to predict outbreak trajectories and evaluate the effects of public health response measures, achieving high MenB vaccination coverage is crucial to help protect at-risk persons during outbreaks of meningococcal disease caused by this serogroup.

Original languageEnglish
Pages (from-to)434-440
Number of pages7
JournalEmerging Infectious Diseases
Issue number3
StatePublished - Mar 2019

Bibliographical note

Funding Information:
Thanks to Paige Batson, Diane Brady, Meagan Burns, Paul Cieslak, George Corey, Michael Day, Charity Dean, Charlie Fautin, Mary Ferris, Stephen Fleming, Michael Gosciminski, George Han, Jennie Haubenreiser, Catherine Kelleher, Jennifer Kyle, Pat Luedtke, Peggie Robinson, Jill Rovaris, Stephanie Schauer, Bruce Thomson, Johanna Vostok, the University of Wisconsin-Madison Health Services, and CDC’s Bacterial Meningitis Laboratory.

Publisher Copyright:
© 2019, Centers for Disease Control and Prevention (CDC). All rights reserved.

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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