University of kentucky sanders-brown healthy brain aging volunteers: Donor characteristics, procedures and neuropathology

Frederick A. Schmitt; Peter T. Nelson; Erin Abner; Stephen Scheff; Gregory A. Jicha; Charles Smith; Gregory Cooper; Marta Mendiondo; Deborah D. Danner; Linda J. van Eldik; Allison Caban-Holt; Mark A. Lovell; Richard J. Kryscio

doi:10.2174/156720512801322591

University of kentucky sanders-brown healthy brain aging volunteers: Donor characteristics, procedures and neuropathology

Frederick A. Schmitt, Peter T. Nelson, Erin Abner, Stephen Scheff, Gregory A. Jicha, Charles Smith, Gregory Cooper, Marta Mendiondo, Deborah D. Danner, Linda J. van Eldik, Allison Caban-Holt, Mark A. Lovell, Richard J. Kryscio

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Cognitively intact elderly research volunteers at the University of Kentucky have been recruited, followed longitudinally, and autopsied with extensive neuropathological evaluations since 1989. To date, the cohort has recruited 1,030 individuals with 552 participants being actively followed, 363 deceased, and 273 autopsied. An extensive database has been constructed with continuous updates that include textured clinical, neuropsychological, neuroimaging, and pathological information. The history, demographics, clinical observations, and pathological features of this research cohort are described. We also explain some of the evolving methodologies and the academic contributions that have been made due to this motivated group of older Kentuckians.

Original language	English
Pages (from-to)	724-733
Number of pages	10
Journal	Current Alzheimer Research
Volume	9
Issue number	6
DOIs	https://doi.org/10.2174/156720512801322591
State	Published - Jul 2012

Keywords

Aging
Alzheimer's
Autopsy
Brain
Dementia
Lewy bodies
Longitudinal
Neuritic plaques
Neurocognition
Neurofibrillary tangles
Neuropathology

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Schmitt, F. A., Nelson, P. T., Abner, E., Scheff, S., Jicha, G. A., Smith, C., Cooper, G., Mendiondo, M., Danner, D. D., van Eldik, L. J., Caban-Holt, A., Lovell, M. A., & Kryscio, R. J. (2012). University of kentucky sanders-brown healthy brain aging volunteers: Donor characteristics, procedures and neuropathology. Current Alzheimer Research, 9(6), 724-733. https://doi.org/10.2174/156720512801322591

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title = "University of kentucky sanders-brown healthy brain aging volunteers: Donor characteristics, procedures and neuropathology",

abstract = "Cognitively intact elderly research volunteers at the University of Kentucky have been recruited, followed longitudinally, and autopsied with extensive neuropathological evaluations since 1989. To date, the cohort has recruited 1,030 individuals with 552 participants being actively followed, 363 deceased, and 273 autopsied. An extensive database has been constructed with continuous updates that include textured clinical, neuropsychological, neuroimaging, and pathological information. The history, demographics, clinical observations, and pathological features of this research cohort are described. We also explain some of the evolving methodologies and the academic contributions that have been made due to this motivated group of older Kentuckians.",

keywords = "Aging, Alzheimer's, Autopsy, Brain, Dementia, Lewy bodies, Longitudinal, Neuritic plaques, Neurocognition, Neurofibrillary tangles, Neuropathology",

author = "Schmitt, {Frederick A.} and Nelson, {Peter T.} and Erin Abner and Stephen Scheff and Jicha, {Gregory A.} and Charles Smith and Gregory Cooper and Marta Mendiondo and Danner, {Deborah D.} and {van Eldik}, {Linda J.} and Allison Caban-Holt and Lovell, {Mark A.} and Kryscio, {Richard J.}",

year = "2012",

month = jul,

doi = "10.2174/156720512801322591",

language = "English",

volume = "9",

pages = "724--733",

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Schmitt, FA , Nelson, PT , Abner, E, Scheff, S, Jicha, GA, Smith, C, Cooper, G, Mendiondo, M, Danner, DD, van Eldik, LJ, Caban-Holt, A, Lovell, MA & Kryscio, RJ 2012, 'University of kentucky sanders-brown healthy brain aging volunteers: Donor characteristics, procedures and neuropathology', Current Alzheimer Research, vol. 9, no. 6, pp. 724-733. https://doi.org/10.2174/156720512801322591

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AU - Schmitt, Frederick A.

AU - Nelson, Peter T.

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AU - Scheff, Stephen

AU - Jicha, Gregory A.

AU - Smith, Charles

AU - Cooper, Gregory

AU - Mendiondo, Marta

AU - Danner, Deborah D.

AU - van Eldik, Linda J.

AU - Caban-Holt, Allison

AU - Lovell, Mark A.

AU - Kryscio, Richard J.

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KW - Lewy bodies

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KW - Neurofibrillary tangles

KW - Neuropathology

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University of kentucky sanders-brown healthy brain aging volunteers: Donor characteristics, procedures and neuropathology

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