TY - JOUR
T1 - University of kentucky sanders-brown healthy brain aging volunteers
T2 - Donor characteristics, procedures and neuropathology
AU - Schmitt, Frederick A.
AU - Nelson, Peter T.
AU - Abner, Erin
AU - Scheff, Stephen
AU - Jicha, Gregory A.
AU - Smith, Charles
AU - Cooper, Gregory
AU - Mendiondo, Marta
AU - Danner, Deborah D.
AU - van Eldik, Linda J.
AU - Caban-Holt, Allison
AU - Lovell, Mark A.
AU - Kryscio, Richard J.
PY - 2012/7
Y1 - 2012/7
N2 - Cognitively intact elderly research volunteers at the University of Kentucky have been recruited, followed longitudinally, and autopsied with extensive neuropathological evaluations since 1989. To date, the cohort has recruited 1,030 individuals with 552 participants being actively followed, 363 deceased, and 273 autopsied. An extensive database has been constructed with continuous updates that include textured clinical, neuropsychological, neuroimaging, and pathological information. The history, demographics, clinical observations, and pathological features of this research cohort are described. We also explain some of the evolving methodologies and the academic contributions that have been made due to this motivated group of older Kentuckians.
AB - Cognitively intact elderly research volunteers at the University of Kentucky have been recruited, followed longitudinally, and autopsied with extensive neuropathological evaluations since 1989. To date, the cohort has recruited 1,030 individuals with 552 participants being actively followed, 363 deceased, and 273 autopsied. An extensive database has been constructed with continuous updates that include textured clinical, neuropsychological, neuroimaging, and pathological information. The history, demographics, clinical observations, and pathological features of this research cohort are described. We also explain some of the evolving methodologies and the academic contributions that have been made due to this motivated group of older Kentuckians.
KW - Aging
KW - Alzheimer's
KW - Autopsy
KW - Brain
KW - Dementia
KW - Lewy bodies
KW - Longitudinal
KW - Neuritic plaques
KW - Neurocognition
KW - Neurofibrillary tangles
KW - Neuropathology
UR - http://www.scopus.com/inward/record.url?scp=84863558172&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863558172&partnerID=8YFLogxK
U2 - 10.2174/156720512801322591
DO - 10.2174/156720512801322591
M3 - Article
C2 - 22471862
AN - SCOPUS:84863558172
SN - 1567-2050
VL - 9
SP - 724
EP - 733
JO - Current Alzheimer Research
JF - Current Alzheimer Research
IS - 6
ER -