Unraveling the risk factors for spontaneous intracerebral hemorrhage among West Africans

Fred S. Sarfo, Bruce Ovbiagele, Mulugeta Gebregziabher, Onoja Akpa, Albert Akpalu, Kolawole Wahab, Godwin Ogbole, Rufus Akinyemi, Reginald Obiako, Morenikeji Komolafe, Lukman Owolabi, Daniel Lackland, Donna Arnett, Hemant Tiwari, Hugh S. Markus, Joshua Akinyemi, Ayodipupo Oguntade, Bimbo Fawale, Abiodun Adeoye, Obiabo OlugboLuqman Ogunjimi, Godwin Osaigbovo, Carolyn Jenkins, Ijezie Chukwuonye, Olabamiji Ajose, Lekan Oyinloye, Fedelis Mutiso, Ruth Laryea, Benedict Calys-Tagoe, Abdul Salaam, Ganiyu Amusa, Samuel Olowookere, Chidiebere Imoh, Aliyu Mande, Oyedunni Arulogun, Fakunle Adekunle, Lambert Appiah, Olayemi Balogun, Arti Singh, Osi Adeleye, Okechukwu Ogah, Akintomiwa Makanjuola, Dorcas Owusu, Philip Kolo, Oladimeji Adebayo, Atinuke Agunloye, Vincent Shidali, Moyinoluwalogo Faniyan, Sulaiman Lakoh, Samuel Diala, Henry Iheonye, Chika Efidi, Emmanuel Sanya, Taofiki Sunmonu, Adeseye Akintunde, Mayowa Owolabi

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

ObjectiveTo characterize risk factors for spontaneous intracerebral hemorrhage (sICH) occurrence and severity among West Africans.MethodsThe Stroke Investigative Research and Educational Network (SIREN) study is a multicenter case-control study involving 15 sites in Ghana and Nigeria. Patients were adults ≥18 years old with CT-confirmed sICH with age-, sex-, and ethnicity-matched stroke-free community controls. Standard instruments were used to assess vascular, lifestyle, and psychosocial factors. Factors associated with sICH and its severity were assessed using conditional logistic regression to estimate odds ratios (ORs) and population-attributable risks (PARs) with 95% confidence intervals (CIs) for factors.ResultsOf 2,944 adjudicated stroke cases, 854 were intracerebral hemorrhage (ICH). Mean age of patients with ICH was 54.7 ± 13.9 years, with a male preponderance (63.1%), and 77.3% were nonlobar. Etiologic subtypes of sICH included hypertension (80.9%), structural vascular anomalies (4.0%), cerebral amyloid angiopathy (0.7%), systemic illnesses (0.5%), medication-related (0.4%), and undetermined (13.7%). Eight factors independently associated with sICH occurrence by decreasing order of PAR with their adjusted OR (95% CI) were hypertension, 66.63 (20.78-213.72); dyslipidemia, 2.95 (1.84-4.74); meat consumption, 1.55 (1.01-2.38); family history of CVD, 2.22 (1.41-3.50); nonconsumption of green vegetables, 3.61 (2.07-6.31); diabetes mellitus, 2.11 (1.29-3.46); stress, 1.68 (1.03-2.77); and current tobacco use, 14.27 (2.09-97.47). Factors associated with severe sICH using an NIH Stroke Scale score >15 with adjusted OR (95% CI) were nonconsumption of leafy green vegetables, 2.03 (1.43-2.88); systolic blood pressure for each mm Hg rise, 1.01 (1.00-1.01); presence of midline shift, 1.54 (1.11-2.13); lobar ICH, 1.72 (1.16-2.55); and supratentorial bleeds, 2.17 (1.06-4.46).ConclusionsPopulation-level control of the dominant factors will substantially mitigate the burden of sICH in West Africa.

Original languageEnglish
Pages (from-to)e998-e1012
JournalNeurology
Volume94
Issue number10
DOIs
StatePublished - Mar 10 2020

Bibliographical note

Publisher Copyright:
© American Academy of Neurology.

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Unraveling the risk factors for spontaneous intracerebral hemorrhage among West Africans'. Together they form a unique fingerprint.

Cite this