Unusual pyranosyl cembranoid diterpene from sarcophyton trocheliophorum

Mohamed Shaaban, Mohamed A. Ghani, Khaled A. Shaaban

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

9-Hydroxy-10,11-dehydro-sarcotrocheliol (1), a new pyrane-based cembranoid diterpene, has been isolated along with three other known compounds, namely, sarcotrocheliol acetate (2), (+)-sarcophytol A (3), and (-)-sarcophytonin A (4), from the organic extract of the soft coral Sarcophyton trocheliophorum. The chemical structures of compounds 1-4 were determined on the basis of their 1D and 2D NMR [1H, 13C, 1H-1H correlation spectroscopy, heteronuclear multiple-quantum coherence, heteronuclear multiple-bond correlation, and nuclear Overhauser effect (NOE)] and mass spectra [electron ionization (EI), electrospray ionization, and high resolution mass spectrometry (HRMS)], and by comparison with related structures. The compounds 1-4 showed neither antimicrobial activity against 11 diverse tested microorganisms, nor cytotoxicity against brine shrimp, whereas the soft coral extract showed low cytotoxicity with a mortality rate of 1.7%.

Original languageEnglish
Pages (from-to)1211-1217
Number of pages7
JournalZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
Volume71
Issue number12
DOIs
StatePublished - Dec 2016

Bibliographical note

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

  • Biological activity
  • Cembranoids
  • Sarcophyton trocheliophorum

ASJC Scopus subject areas

  • General Chemistry

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