TY - JOUR
T1 - Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology
T2 - a systematic review
AU - Akinyemi, Amos Olalekan
AU - Simpson, Kendall Elizabeth
AU - Oyelere, Sunday Faith
AU - Nur, Maria
AU - Ngule, Chrispus Mutuku
AU - Owoyemi, Bolaji Charles Dayo
AU - Ayarick, Vivian Adiila
AU - Oyelami, Felix Femi
AU - Obaleye, Oluwafunminiyi
AU - Esoe, Dave Preston
AU - Liu, Xiaoqi
AU - Li, Zhiguo
N1 - Publisher Copyright:
© 2023, The Feinstein Institute for Medical Research.
PY - 2023/12
Y1 - 2023/12
N2 - Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial role in protein folding by assisting in the assembly of misfolded proteins. Under cellular stress conditions, GRP78 can translocate to the cell surface (csGRP78) were it interacts with different ligands to initiate various intracellular pathways. The expression of csGRP78 has been associated with tumor initiation and progression of multiple cancer types. This review provides a comprehensive analysis of the existing evidence on the roles of GRP78 in various types of cancer and other human pathology. Additionally, the review discusses the current understanding of the mechanisms underlying GRP78's involvement in tumorigenesis and cancer advancement. Furthermore, we highlight recent innovative approaches employed in downregulating GRP78 expression in cancers as a potential therapeutic target.
AB - Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial role in protein folding by assisting in the assembly of misfolded proteins. Under cellular stress conditions, GRP78 can translocate to the cell surface (csGRP78) were it interacts with different ligands to initiate various intracellular pathways. The expression of csGRP78 has been associated with tumor initiation and progression of multiple cancer types. This review provides a comprehensive analysis of the existing evidence on the roles of GRP78 in various types of cancer and other human pathology. Additionally, the review discusses the current understanding of the mechanisms underlying GRP78's involvement in tumorigenesis and cancer advancement. Furthermore, we highlight recent innovative approaches employed in downregulating GRP78 expression in cancers as a potential therapeutic target.
KW - BiP
KW - Cancer
KW - Chaperon
KW - Disease
KW - ER stress
KW - ERAD
KW - GRP78
KW - URP
UR - http://www.scopus.com/inward/record.url?scp=85168459940&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85168459940&partnerID=8YFLogxK
U2 - 10.1186/s10020-023-00706-6
DO - 10.1186/s10020-023-00706-6
M3 - Review article
C2 - 37605113
AN - SCOPUS:85168459940
SN - 1076-1551
VL - 29
JO - Molecular Medicine
JF - Molecular Medicine
IS - 1
M1 - 112
ER -
