TY - JOUR
T1 - Up-regulated expression of scavenger receptor class B type 1 (SR-B1) is associated with malignant behaviors and poor prognosis of breast cancer
AU - Li, Juan
AU - Wang, Jing
AU - Li, Ming
AU - Yin, Linlin
AU - Li, Xiang An
AU - Zhang, Ting Guo
N1 - Publisher Copyright:
© 2016 Elsevier GmbH
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Scavenger receptor class B type 1 (SR-B1) is an integral membrane protein that is expressed in numerous cells and tissue types. The primary role of SR-B1 is to facilitate uptake of cholesteryl esters from high-density lipoproteins (HDL) in the liver. Altered SR-B1 expression contributes to human diseases. This study assessed association of SR-B1 expression in breast tissue specimens with breast cancer development and prognosis. Tissue specimens from 30 cases of adjacent normal breast tissues, ductal carcinoma in situ (DCIS) and invasive ductal breast cancer (IDCA) were subjected to Western blot analysis, and 135 cases of DCIS and IDCA were used for quantitative immunohistochemical analysis of SR-B1 expression. The data showed that SR-B1 was significantly overexpressed in IDCA tissues compared to normal breast and DCIS tissues. SR-B1 expression was associated with pre-menopausal status, tumor size, and worse overall survival of patients. The data from this ex vivo study suggests that up-regulated SR-B1 protein expression is associated with malignant behaviors of breast cancer and that SR-B1 is an independent predictor for poor survival in breast cancer patients.
AB - Scavenger receptor class B type 1 (SR-B1) is an integral membrane protein that is expressed in numerous cells and tissue types. The primary role of SR-B1 is to facilitate uptake of cholesteryl esters from high-density lipoproteins (HDL) in the liver. Altered SR-B1 expression contributes to human diseases. This study assessed association of SR-B1 expression in breast tissue specimens with breast cancer development and prognosis. Tissue specimens from 30 cases of adjacent normal breast tissues, ductal carcinoma in situ (DCIS) and invasive ductal breast cancer (IDCA) were subjected to Western blot analysis, and 135 cases of DCIS and IDCA were used for quantitative immunohistochemical analysis of SR-B1 expression. The data showed that SR-B1 was significantly overexpressed in IDCA tissues compared to normal breast and DCIS tissues. SR-B1 expression was associated with pre-menopausal status, tumor size, and worse overall survival of patients. The data from this ex vivo study suggests that up-regulated SR-B1 protein expression is associated with malignant behaviors of breast cancer and that SR-B1 is an independent predictor for poor survival in breast cancer patients.
KW - Biomarker
KW - Breast cancer
KW - Prognosis
KW - SRB1
UR - http://www.scopus.com/inward/record.url?scp=84963603458&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84963603458&partnerID=8YFLogxK
U2 - 10.1016/j.prp.2016.03.011
DO - 10.1016/j.prp.2016.03.011
M3 - Article
C2 - 27067809
AN - SCOPUS:84963603458
SN - 0344-0338
VL - 212
SP - 555
EP - 559
JO - Pathology Research and Practice
JF - Pathology Research and Practice
IS - 6
ER -
