Up-regulation of LOX-1 expression by TNF-α promotes trans-endothelial migration of MDA-MB-231 breast cancer cells

Mei Liang, Ping Zhang, Jian Fu

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Adhesion of cancer cell to endothelial cells and the subsequent trans-endothelial migration are key steps in metastasis. However, the identities of the molecules mediating cancer cell/endothelial cell interaction are still not fully understood. In this study, we tested the hypothesis that lectin-like oxidized-low-density lipoprotein (oxLDL) receptor-1 (LOX-1), a key mediator of vascular inflammation and atherosclerosis expressed on endothelial cell surface, mediates breast cancer cell/endothelial cell interactions. We showed that up-regulation of endothelial LOX-1 by TNF-α promoted the adhesion and trans-endothelial migration of MDA-MB-231 breast cancer cells. Thus, endothelial LOX-1 could present a novel pathway in breast cancer metastasis.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalCancer Letters
Volume258
Issue number1
DOIs
StatePublished - Dec 8 2007

Keywords

  • Adhesion
  • Breast cancer
  • Endothelial cells
  • LOX-1
  • Metastasis
  • Migration

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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