TY - JOUR
T1 - Up-regulation of oxytocin receptor expression at term is related to maternal body mass index
AU - Garabedian, Matthew J.
AU - Hansen, Wendy F.
AU - McCord, Lauren A.
AU - Manning, Mark A.
AU - O'Brien, John M.
AU - Curry, Thomas E.
PY - 2013
Y1 - 2013
N2 - Background The likelihood of cesarean is in part related to maternal body mass index (BMI). Myometrial changes may be responsible. Methods Myometrial biopsies were collected from the upper edge of the hysterotomy from women undergoing scheduled cesarean with term, singleton gestations. Oxytocin receptor and connexin-43 mRNA protein expression was quantified with real-time polymerase chain reaction and Western blot. Results Twenty subjects were recruited: 13 repeat and 7 primary cesareans. Oxytocin receptor mRNA was associated with BMI among women undergoing primary (r = 0.75; p = 0.05) but not repeat cesarean (p > 0.05). Controlling for gestational age, this association strengthened (p = 0.004). Receptor protein expression showed a linear correlation with BMI in the primary cesarean group (p = 0.002). Connexin-43 mRNA expression was not related to BMI in women undergoing primary (r = -0.14, p = 0.76) or repeat (r = -0.01, p = 0.86) cesarean. Conclusions Oxytocin receptor, but not connexin-43, expression is related to BMI, suggesting an alteration in oxytocin receptor expression or function related to obesity.
AB - Background The likelihood of cesarean is in part related to maternal body mass index (BMI). Myometrial changes may be responsible. Methods Myometrial biopsies were collected from the upper edge of the hysterotomy from women undergoing scheduled cesarean with term, singleton gestations. Oxytocin receptor and connexin-43 mRNA protein expression was quantified with real-time polymerase chain reaction and Western blot. Results Twenty subjects were recruited: 13 repeat and 7 primary cesareans. Oxytocin receptor mRNA was associated with BMI among women undergoing primary (r = 0.75; p = 0.05) but not repeat cesarean (p > 0.05). Controlling for gestational age, this association strengthened (p = 0.004). Receptor protein expression showed a linear correlation with BMI in the primary cesarean group (p = 0.002). Connexin-43 mRNA expression was not related to BMI in women undergoing primary (r = -0.14, p = 0.76) or repeat (r = -0.01, p = 0.86) cesarean. Conclusions Oxytocin receptor, but not connexin-43, expression is related to BMI, suggesting an alteration in oxytocin receptor expression or function related to obesity.
KW - cesarean delivery
KW - connexin-43
KW - obesity
KW - oxytocin receptor
KW - pregnancy
UR - http://www.scopus.com/inward/record.url?scp=84879131555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879131555&partnerID=8YFLogxK
U2 - 10.1055/s-0032-1329179
DO - 10.1055/s-0032-1329179
M3 - Article
C2 - 23355275
AN - SCOPUS:84879131555
SN - 0735-1631
VL - 30
SP - 491
EP - 497
JO - American Journal of Perinatology
JF - American Journal of Perinatology
IS - 6
ER -