Aortic aneurysms in both abdominal and thoracic aortic regions have complex pathophysiological features. In recent years, a considerable increase in research on aneurysm pathogenesis has resulted in the discovery of novel mechanisms and implementation of clinical trials that seek to assess strategies for preventing aneurysm expansion. Despite progress on our understanding of aortic aneurysms, there are still many unanswered questions and conflicting findings requiring clarification. This uncertainty highlights the importance of continual cooperation between preclinical and clinical researchers in validating findings from preclinical studies to the human disease, to discover medical treatments that prevent or halt the progression of aortic aneurysmal disease. We hope that this brief review prompts interest in reading these highlighted articles and spurs further investigation into this complex and devastating disease.
|Journal||Arteriosclerosis, Thrombosis, and Vascular Biology|
|State||Published - Mar 1 2019|
Bibliographical noteFunding Information:
The research work of F.M. Davis is supported by National Institutes of Health (NIH) NIH-F32 DK-117545-01, American College of Surgeons, and the Vascular and Endovascular Surgery Society. Research work of A. Daugherty and H.S. Lu was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under award numbers R01HL133723 and R01HL139748 and the American Heart Association SFRN in Vascular Disease (18SFRN33960163). The content in this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or other institutions.
© 2019 American Heart Association, Inc.
- aortic aneurysm
- aortic rupture
- sex differences
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine