TY - JOUR
T1 - Urine miRNAs as potential biomarkers for systemic reactions induced by exposure to embedded metal
AU - Vechetti, Ivan J.
AU - Wen, Yuan
AU - Hoffman, Jessica F.
AU - Alimov, Alexander P.
AU - Vergara, Vernieda B.
AU - Kalinich, John F.
AU - Gaitens, Joanna M.
AU - Hines, Stella E.
AU - McDiarmid, Melissa A.
AU - McCarthy, John J.
AU - Peterson, Charlotte A.
N1 - Publisher Copyright:
© 2021 Future Medicine Ltd.
PY - 2021/10
Y1 - 2021/10
N2 - Aim: Explore the potential of urine microRNAs as biomarkers that may reflect the biological responses to pure metals embedded in skeletal muscle over time. Materials & methods: We tested a panel of military-relevant metals embedded in the gastrocnemius muscles of 3-month-old, male, Sprague-Dawley rats (n = 8/group) for a duration of 1, 3, 6 and 12 months, and performed small RNA-sequencing on the urine samples. Results: Results provide potential tissue targets affected by metal exposure and a list of unique or common urine microRNA biomarkers indicative of exposure to various metals, highlighting a complex systemic response. Conclusion: We have identified a panel of miRNAs as potential urine biomarkers to reflect the complex systemic response to embedded metal exposure.
AB - Aim: Explore the potential of urine microRNAs as biomarkers that may reflect the biological responses to pure metals embedded in skeletal muscle over time. Materials & methods: We tested a panel of military-relevant metals embedded in the gastrocnemius muscles of 3-month-old, male, Sprague-Dawley rats (n = 8/group) for a duration of 1, 3, 6 and 12 months, and performed small RNA-sequencing on the urine samples. Results: Results provide potential tissue targets affected by metal exposure and a list of unique or common urine microRNA biomarkers indicative of exposure to various metals, highlighting a complex systemic response. Conclusion: We have identified a panel of miRNAs as potential urine biomarkers to reflect the complex systemic response to embedded metal exposure.
KW - RNA sequencing
KW - microRNA
KW - military metals
KW - skeletal muscle
KW - urine biomarkers
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U2 - 10.2217/bmm-2021-0120
DO - 10.2217/bmm-2021-0120
M3 - Article
C2 - 34541869
AN - SCOPUS:85116346024
SN - 1752-0363
VL - 15
SP - 1397
EP - 1410
JO - Biomarkers in Medicine
JF - Biomarkers in Medicine
IS - 15
ER -