Urine miRNAs as potential biomarkers for systemic reactions induced by exposure to embedded metal

Ivan J. Vechetti, Yuan Wen, Jessica F. Hoffman, Alexander P. Alimov, Vernieda B. Vergara, John F. Kalinich, Joanna M. Gaitens, Stella E. Hines, Melissa A. McDiarmid, John J. McCarthy, Charlotte A. Peterson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Aim: Explore the potential of urine microRNAs as biomarkers that may reflect the biological responses to pure metals embedded in skeletal muscle over time. Materials & methods: We tested a panel of military-relevant metals embedded in the gastrocnemius muscles of 3-month-old, male, Sprague-Dawley rats (n = 8/group) for a duration of 1, 3, 6 and 12 months, and performed small RNA-sequencing on the urine samples. Results: Results provide potential tissue targets affected by metal exposure and a list of unique or common urine microRNA biomarkers indicative of exposure to various metals, highlighting a complex systemic response. Conclusion: We have identified a panel of miRNAs as potential urine biomarkers to reflect the complex systemic response to embedded metal exposure.

Original languageEnglish
Pages (from-to)1397-1410
Number of pages14
JournalBiomarkers in Medicine
Issue number15
StatePublished - Oct 2021

Bibliographical note

Publisher Copyright:
© 2021 Future Medicine Ltd.


  • RNA sequencing
  • microRNA
  • military metals
  • skeletal muscle
  • urine biomarkers

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical


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