TY - JOUR
T1 - Use of beat-to-beat cardiovascular variability data to determine the validity of sham therapy as the placebo control in osteopathic manipulative medicine research
AU - Henley, Charles E.
AU - Wilson, Thad E.
N1 - Publisher Copyright:
© 2014 American Osteopathic Association.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Osteopathic manipulative medicine researchers often use sham therapy as the placebo control during clinical trials. Optimally, the sham therapy should be a hands-on procedure that is perceptually indistinguishable from osteopathic manipulative treatment, does not create an effect on its own, and is not a treatment intervention. However, the sham therapy itself may often influence the outcome. The use of cardiovascular variability (eg, beat-to-beat heart rate variability) as a surrogate for the autonomic nervous system is one objective method by which to identify such an effect. By monitoring cardiovascular variability, investigators can assess autonomic nervous system activity as a response to the sham therapy and quickly determine whether or not the selected sham therapy is a true placebo control.
AB - Osteopathic manipulative medicine researchers often use sham therapy as the placebo control during clinical trials. Optimally, the sham therapy should be a hands-on procedure that is perceptually indistinguishable from osteopathic manipulative treatment, does not create an effect on its own, and is not a treatment intervention. However, the sham therapy itself may often influence the outcome. The use of cardiovascular variability (eg, beat-to-beat heart rate variability) as a surrogate for the autonomic nervous system is one objective method by which to identify such an effect. By monitoring cardiovascular variability, investigators can assess autonomic nervous system activity as a response to the sham therapy and quickly determine whether or not the selected sham therapy is a true placebo control.
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U2 - 10.7556/jaoa.2014.172
DO - 10.7556/jaoa.2014.172
M3 - Article
C2 - 25352407
AN - SCOPUS:84925304855
SN - 0098-6151
VL - 114
SP - 860
EP - 866
JO - Journal of the American Osteopathic Association
JF - Journal of the American Osteopathic Association
IS - 11
ER -