TY - JOUR
T1 - Use of mucosal immunization with porcine zona pellucida (PZP) in mice and rabbits
AU - Martin, Brent J.
AU - Suckow, Mark A.
AU - Wolter, William R.
AU - Berger, Thomas
AU - Turner, John W.
PY - 2006/7
Y1 - 2006/7
N2 - Rabbits (Oryctolagus cuniculus) and two strains of mice (Mus musculus, one inbred and one outbred) were immunized against porcine zona pellucida (PZP) antigen. Alginate microspheres or cholera toxin B were used alone or in combination when mucosal immunization routes were used. Serum antibody responses and fertility were assessed. Neither rabbit or mouse groups immunized by mucosal routes generated significant antibody responses to PZP as compared to parenteral immunization (ANOVA, P > 0.05). The study shows that porcine zona pellucida is not an effective mucosal antigen in small mammals.
AB - Rabbits (Oryctolagus cuniculus) and two strains of mice (Mus musculus, one inbred and one outbred) were immunized against porcine zona pellucida (PZP) antigen. Alginate microspheres or cholera toxin B were used alone or in combination when mucosal immunization routes were used. Serum antibody responses and fertility were assessed. Neither rabbit or mouse groups immunized by mucosal routes generated significant antibody responses to PZP as compared to parenteral immunization (ANOVA, P > 0.05). The study shows that porcine zona pellucida is not an effective mucosal antigen in small mammals.
KW - Alginate microsphere
KW - Mouse
KW - Mucosal immunity
KW - PZP
KW - Porcine zona pellucida
KW - Rabbit
UR - http://www.scopus.com/inward/record.url?scp=33646777127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646777127&partnerID=8YFLogxK
U2 - 10.1016/j.anireprosci.2005.09.007
DO - 10.1016/j.anireprosci.2005.09.007
M3 - Article
C2 - 16249060
AN - SCOPUS:33646777127
SN - 0378-4320
VL - 93
SP - 372
EP - 378
JO - Animal Reproduction Science
JF - Animal Reproduction Science
IS - 3-4
ER -
