Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study

Charles E. Green; Jon E. Tyson; Roy J. Heyne; Susan R. Hintz; Betty R. Vohr; Carla M. Bann; Abhik Das; Edward F. Bell; Sana Boral Debsareea; Emily Stephens; Marie G. Gantz; Carolyn M. Petrie Huitema; Karen J. Johnson; Kristi L. Watterberg; Ricardo Mosquera; Myriam Peralta-Carcelen; Deanne E. Wilson-Costello; Tarah T. Colaizy; Nathalie L. Maitre; Stephanie L. Merhar; Ira Adams-Chapman; Janell Fuller; Michelle E. Hartley-McAndrew; William F. Malcolm; Sarah Winter; Andrea F. Duncan; Gary J. Myer; Stephen D. Kicklighter; Myra H. Wyckoff; Sara B. DeMauro; Anna Maria Hibbs; Barbara J. Stoll; Waldemar A. Carlo; Krisa P. Van Meurs; Matthew A. Rysavy; Ravi M. Patel; Pablo J. Sánchez; Abbot R. Laptook; C. Michael Cotten; Carl T. D’Angio; Michele C. Walsh; Richard A. Polin; Martin Keszler; Angelita M. Hensman; Elisa Vieira; Lucille St Pierre; Robert T. Burke; Barbara Alksninis; Andrea Knoll; Mary L. Keszler; Teresa M. Leach; Elisabeth C. McGowan; Victoria E. Watson; Nancy S. Newman; Bonnie S. Siner; Elizabeth Roth; Angelia Williams; Brenda B. Poindexter; Kurt Schibler; K. Tanya E. Cahill; Cathy Grisby; Kristin Kirker; Sara Stacey; Sandra Wuertz; Ronald N. Goldberg; Ricki F. Goldstein; Patricia L. Ashley; Deesha Mago-Shah; Joanne Finkle; Kimberley A. Fisher; Kathryn E. Gustafson; Caitlin Stone; Matthew M. Laughon; Janice Bernhardt; Janice Wereszczak; Jennifer Talbert; Alexandra Bentley; Laura Edwards; Ginger Rhodes-Ryan; Donna White; David P. Carlton; Yvonne Loggins; Diane Bottcher; Sheena L. Carter; Salathiel Kendrick-Allwood; Maureen Mulligan LaRossa; Judith Laursen; Colleen Mackie; Amy Sanders; Gloria Smikle; Lynn Wineski; Andrew A. Bremer; Rosemary D. Higgins; Stephanie Wilson Archer; Amir M. Khan; Kathleen A. Kennedy; Andrea F. Duncan; Elizabeth Allain; Julie Arldt-McAlister; Fatima Boricha; Allison G. Dempsey; Carmen Garcia; Donna J. Hall; Janice John; M. Layne Lillie; Karen Martin; Georgia E. McDavid; Shannon L. McKee; Michelle Poe; Kimberly Rennie; Tina Reddy; Shawna Rodgers; Daniel K. Sperry; Sharon L. Wright; Leif D. Nelin; Jonathan L. Slaughter; Sudarshan R. Jadcherla; Christopher Timan; Patricia Luzader; Melanie Stein; Rox Ann Sullivan; Helen Carey; Stephanie Burkhardt; Mary Ann Nelin; Erna Clark; Kristi Small; Jacqueline McCool; Lindsay Pietruszewski; Jessica Purnell; Kyrstin Warnimont; Laura Marzec; Bethany Miller; Demi R. Beckford; Hallie Baugher; Katelyn Levengood; Nancy Batterson; Jill Tonneman; Krystal Hay; Brittany DeSantis; Dennis Wallace; Jeanette O’ Donnell Auman; Margaret Crawford; Jenna Gabrio; Jamie E. Newman; Lindsay Parlberg; Kristin M. Zaterka-Baxter; David K. Stevenson; M. Bethany Ball; Valerie Chock; Dona Bahmani; Barbara Bentley; Maria Elena DeAnda; Anne M. DeBattista; Beth Earhart; Lynne C. Huffman; Casey E. Krueger; Ryan E. Lucash; Heather Taylor; Hali E. Weiss; Namasivayam Ambalavanan; Kirstin J. Bailey; Fred J. Biasini; Stephanie A. Chopko; Monica V. Collins; Shirley S. Cosby; Kristy A. Domnanovich; Chantel J. Jno-Finn; Morissa Ladinsky; Mary Beth Moses; Tara E. McNair; Vivien A. Phillips; Julie Preskitt; Richard V. Rector; Kimberlly Stringer; Sally Whitley; Sheree York Chapman; Heidi M. Harmon; Karen J. Johnson; Mendi L. Schmelzel; Jacky R. Walker; Claire A. Goeke; Sarah E. Faruqui; Diane L. Eastman; Michelle L. Baack; Laurie A. Hogden; Megan M. Henning; Chelsey Elenkiwich; Megan Broadbent; Sarah Van Muyden; Robin K. Ohls; Conra Backstrom Lacy; Sandra Sundquist Beauman; Mary Ruffner Hanson; Jean R. Lowe; Elizabeth Kuan; Eric C. Eichenwald; Barbara Schmidt; Haresh Kirpalani; Soraya Abbasi; Aasma S. Chaudhary; Toni Mancini; Jonathan Snyder; Kristina Ziolkowski; Ronnie Guillet; Satyan Lakshminrusimha; Anne Marie Reynolds; Rosemary L. Jensen; Joan Merzbach; William Zorn; Osman Farooq; Gary J. Myers; Mary Rowan; Diane Prinzing; Melissa Bowman; Ann Marie Scorsone; Kyle Binion; Constance Orme; Premini Sabaratnam; Alison Kent; Rachel Jones; Elizabeth Boylin; Emily Li; Jennifer Kachelmeyer; Kimberly G. McKee; Kelly R. Coleman; Brenna Cavanaugh; Luc P. Brion; Diana M. Vasil; Sally S. Adams; Frances Eubanks; E. Rebecca McDougald; Lara Pavageau; Pollieanna Sepulveda; Alicia Guzman; Elizabeth Heyne; Lizette E. Lee; Azucena Vera; Jillian Waterbury; Cathy Twell Boatman; Bradley A. Yoder; Mariana Baserga; Roger G. Faix; Stephen D. Minton; Mark J. Sheffield; Carrie A. Rau; Shawna Baker; Susan Christensen; Sean D. Cunningham; Jennifer O. Elmont; Becky Hall; Erika R. Jensen; Manndi C. Loertscher; Trisha Marchant; Kandace M. McGrath; Hena G. Mickelsen; Galina Morshedzadeh; D. Melody Parry; Kelly Stout; Ashley L. Stuart; Kimberlee Weaver-Lewis

doi:10.1038/s41372-023-01729-x

Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study

Charles E. Green, Jon E. Tyson, Roy J. Heyne, Susan R. Hintz, Betty R. Vohr, Carla M. Bann, Abhik Das, Edward F. Bell, Sana Boral Debsareea, Emily Stephens, Marie G. Gantz, Carolyn M. Petrie Huitema, Karen J. Johnson, Kristi L. Watterberg, Ricardo Mosquera, Myriam Peralta-Carcelen, Deanne E. Wilson-Costello, Tarah T. Colaizy, Nathalie L. Maitre, Stephanie L. MerharIra Adams-Chapman, Janell Fuller, Michelle E. Hartley-McAndrew, William F. Malcolm, Sarah Winter, Andrea F. Duncan, Gary J. Myer, Stephen D. Kicklighter, Myra H. Wyckoff, Sara B. DeMauro, Anna Maria Hibbs, Barbara J. Stoll, Waldemar A. Carlo, Krisa P. Van Meurs, Matthew A. Rysavy, Ravi M. Patel, Pablo J. Sánchez, Abbot R. Laptook, C. Michael Cotten, Carl T. D’Angio, Michele C. Walsh, Richard A. Polin, Martin Keszler, Angelita M. Hensman, Elisa Vieira, Lucille St Pierre, Robert T. Burke, Barbara Alksninis, Andrea Knoll, Mary L. Keszler, Teresa M. Leach, Elisabeth C. McGowan, Victoria E. Watson, Nancy S. Newman, Bonnie S. Siner, Elizabeth Roth, Angelia Williams, Brenda B. Poindexter, Kurt Schibler, K. Tanya E. Cahill, Cathy Grisby, Kristin Kirker, Sara Stacey, Sandra Wuertz, Ronald N. Goldberg, Ricki F. Goldstein, Patricia L. Ashley, Deesha Mago-Shah, Joanne Finkle, Kimberley A. Fisher, Kathryn E. Gustafson, Caitlin Stone, Matthew M. Laughon, Janice Bernhardt, Janice Wereszczak, Jennifer Talbert, Alexandra Bentley, Laura Edwards, Ginger Rhodes-Ryan, Donna White, David P. Carlton, Yvonne Loggins, Diane Bottcher, Sheena L. Carter, Salathiel Kendrick-Allwood, Maureen Mulligan LaRossa, Judith Laursen, Colleen Mackie, Amy Sanders, Gloria Smikle, Lynn Wineski, Andrew A. Bremer, Rosemary D. Higgins, Stephanie Wilson Archer, Amir M. Khan, Kathleen A. Kennedy, Andrea F. Duncan, Elizabeth Allain, Julie Arldt-McAlister, Fatima Boricha, Allison G. Dempsey, Carmen Garcia, Donna J. Hall, Janice John, M. Layne Lillie, Karen Martin, Georgia E. McDavid, Shannon L. McKee, Michelle Poe, Kimberly Rennie, Tina Reddy, Shawna Rodgers, Daniel K. Sperry, Sharon L. Wright, Leif D. Nelin, Jonathan L. Slaughter, Sudarshan R. Jadcherla, Christopher Timan, Patricia Luzader, Melanie Stein, Rox Ann Sullivan, Helen Carey, Stephanie Burkhardt, Mary Ann Nelin, Erna Clark, Kristi Small, Jacqueline McCool, Lindsay Pietruszewski, Jessica Purnell, Kyrstin Warnimont, Laura Marzec, Bethany Miller, Demi R. Beckford, Hallie Baugher, Katelyn Levengood, Nancy Batterson, Jill Tonneman, Krystal Hay, Brittany DeSantis, Dennis Wallace, Jeanette O’ Donnell Auman, Margaret Crawford, Jenna Gabrio, Jamie E. Newman, Lindsay Parlberg, Kristin M. Zaterka-Baxter, David K. Stevenson, M. Bethany Ball, Valerie Chock, Dona Bahmani, Barbara Bentley, Maria Elena DeAnda, Anne M. DeBattista, Beth Earhart, Lynne C. Huffman, Casey E. Krueger, Ryan E. Lucash, Heather Taylor, Hali E. Weiss, Namasivayam Ambalavanan, Kirstin J. Bailey, Fred J. Biasini, Stephanie A. Chopko, Monica V. Collins, Shirley S. Cosby, Kristy A. Domnanovich, Chantel J. Jno-Finn, Morissa Ladinsky, Mary Beth Moses, Tara E. McNair, Vivien A. Phillips, Julie Preskitt, Richard V. Rector, Kimberlly Stringer, Sally Whitley, Sheree York Chapman, Heidi M. Harmon, Karen J. Johnson, Mendi L. Schmelzel, Jacky R. Walker, Claire A. Goeke, Sarah E. Faruqui, Diane L. Eastman, Michelle L. Baack, Laurie A. Hogden, Megan M. Henning, Chelsey Elenkiwich, Megan Broadbent, Sarah Van Muyden, Robin K. Ohls, Conra Backstrom Lacy, Sandra Sundquist Beauman, Mary Ruffner Hanson, Jean R. Lowe, Elizabeth Kuan, Eric C. Eichenwald, Barbara Schmidt, Haresh Kirpalani, Soraya Abbasi, Aasma S. Chaudhary, Toni Mancini, Jonathan Snyder, Kristina Ziolkowski, Ronnie Guillet, Satyan Lakshminrusimha, Anne Marie Reynolds, Rosemary L. Jensen, Joan Merzbach, William Zorn, Osman Farooq, Gary J. Myers, Mary Rowan, Diane Prinzing, Melissa Bowman, Ann Marie Scorsone, Kyle Binion, Constance Orme, Premini Sabaratnam, Alison Kent, Rachel Jones, Elizabeth Boylin, Emily Li, Jennifer Kachelmeyer, Kimberly G. McKee, Kelly R. Coleman, Brenna Cavanaugh, Luc P. Brion, Diana M. Vasil, Sally S. Adams, Frances Eubanks, E. Rebecca McDougald, Lara Pavageau, Pollieanna Sepulveda, Alicia Guzman, Elizabeth Heyne, Lizette E. Lee, Azucena Vera, Jillian Waterbury, Cathy Twell Boatman, Bradley A. Yoder, Mariana Baserga, Roger G. Faix, Stephen D. Minton, Mark J. Sheffield, Carrie A. Rau, Shawna Baker, Susan Christensen, Sean D. Cunningham, Jennifer O. Elmont, Becky Hall, Erika R. Jensen, Manndi C. Loertscher, Trisha Marchant, Kandace M. McGrath, Hena G. Mickelsen, Galina Morshedzadeh, D. Melody Parry, Kelly Stout, Ashley L. Stuart, Kimberlee Weaver-Lewis

Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Objective: Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. Study design: Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age. Results: We assessed 1452 EP infants and 183 TR infants. TR-based thresholds showed higher overall EP impairment than Bayley norm-based thresholds (O.R. = 1.86; [95% CI 1.56–2.23], especially for severe impairment (36% vs. 24%; p ≤ 0.001). Difficulty recruiting TR patients at 2 years extended the study by 14 months and affected their demographics. Conclusion: Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. ClinicalTrials.gov ID: Term Reference (under the Generic Database Study): NCT00063063.

Original language	English
Pages (from-to)	1398-1405
Number of pages	8
Journal	Journal of Perinatology
Volume	43
Issue number	11
DOIs	https://doi.org/10.1038/s41372-023-01729-x
State	Published - Nov 2023

Bibliographical note

Publisher Copyright:
© 2023, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.

Funding

The National Institutes of Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (U10 HD21373, UG1 HD21364, UG1 HD21385, UG1 HD27851, UG1 HD27853, UG1 HD27856, UG1 HD27880,UG1 HD27904, UG1 HD34216, UG1 HD36790, UG1 HD40492, UG1 HD40689, UG1 HD53089, UG1 HD53109, UG1 HD68244, UG1 HD68270, UG1 HD68278, UG1 HD68263, UG1 HD68284; UG1 HD87226, UG1 HD87229) and the National Center for Advancing Translational Sciences (NCATS) (UL1 TR6, UL1 TR41, UL1 TR42, UL1 TR77, UL1 TR93, UL1 TR105, UL1 TR442, UL1 TR454, UL1 TR1117, provided grant support for the Neonatal Research Network, including for the Follow-up Study. The National Institutes of Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) provided grant support for the Neonatal Research Network for the Term Reference Study. NICHD staff provided input into the study design, conduct, analysis, and manuscript drafting; NCATS cooperative agreements provided infrastructure support to the NRN. While NICHD staff had input into the study design, conduct, analysis, and manuscript drafting, the comments and views of the authors do not necessarily represent the views of NICHD, the National Institutes of Health, the Department of Health and Human Services, or the U.S. Government.

Funders	Funder number
Neonatal Research Network
National Institutes of Health (NIH)
U.S. Department of Health and Human Services
National Center for Advancing Translational Sciences (NCATS)	UL1 TR105, UL1 TR442, UL1 TR454, UL1 TR1117
National Center for Advancing Translational Sciences (NCATS)
Eunice Kennedy Shriver National Institute of Child Health and Human Development	UG1 HD27851, UG1 HD34216, UG1 HD27853, UG1 HD68270, UG1 HD27856, UG1 HD53109, UG1 HD68284, UG1 HD27904, UG1 HD53089, UG1 HD36790, U10 HD21373, UG1 HD40689, UG1 HD87229, UG1 HD68263, UG1 HD21385, UG1 HD68244, UG1 HD21364, UG1 HD68278, UG1 HD40492, UG1 HD27880, UG1 HD87226
Eunice Kennedy Shriver National Institute of Child Health and Human Development

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

Access to Document

10.1038/s41372-023-01729-x

Cite this

Green, C. E., Tyson, J. E., Heyne, R. J., Hintz, S. R., Vohr, B. R., Bann, C. M., Das, A., Bell, E. F., Debsareea, S. B., Stephens, E., Gantz, M. G., Petrie Huitema, C. M., Johnson, K. J., Watterberg, K. L., Mosquera, R., Peralta-Carcelen, M., Wilson-Costello, D. E., Colaizy, T. T., Maitre, N. L., ... Weaver-Lewis, K. (2023). Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study. Journal of Perinatology, 43(11), 1398-1405. https://doi.org/10.1038/s41372-023-01729-x

@article{d10e00aba9ae4c38b434e7bdef267e07,

title = "Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study",

abstract = "Objective: Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. Study design: Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age. Results: We assessed 1452 EP infants and 183 TR infants. TR-based thresholds showed higher overall EP impairment than Bayley norm-based thresholds (O.R. = 1.86; [95% CI 1.56–2.23], especially for severe impairment (36% vs. 24%; p ≤ 0.001). Difficulty recruiting TR patients at 2 years extended the study by 14 months and affected their demographics. Conclusion: Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. ClinicalTrials.gov ID: Term Reference (under the Generic Database Study): NCT00063063.",

author = "Green, {Charles E.} and Tyson, {Jon E.} and Heyne, {Roy J.} and Hintz, {Susan R.} and Vohr, {Betty R.} and Bann, {Carla M.} and Abhik Das and Bell, {Edward F.} and Debsareea, {Sana Boral} and Emily Stephens and Gantz, {Marie G.} and {Petrie Huitema}, {Carolyn M.} and Johnson, {Karen J.} and Watterberg, {Kristi L.} and Ricardo Mosquera and Myriam Peralta-Carcelen and Wilson-Costello, {Deanne E.} and Colaizy, {Tarah T.} and Maitre, {Nathalie L.} and Merhar, {Stephanie L.} and Ira Adams-Chapman and Janell Fuller and Hartley-McAndrew, {Michelle E.} and Malcolm, {William F.} and Sarah Winter and Duncan, {Andrea F.} and Myer, {Gary J.} and Kicklighter, {Stephen D.} and Wyckoff, {Myra H.} and DeMauro, {Sara B.} and Hibbs, {Anna Maria} and Stoll, {Barbara J.} and Carlo, {Waldemar A.} and {Van Meurs}, {Krisa P.} and Rysavy, {Matthew A.} and Patel, {Ravi M.} and S{\'a}nchez, {Pablo J.} and Laptook, {Abbot R.} and Cotten, {C. Michael} and D{\textquoteright}Angio, {Carl T.} and Walsh, {Michele C.} and Polin, {Richard A.} and Martin Keszler and Hensman, {Angelita M.} and Elisa Vieira and Pierre, {Lucille St} and Burke, {Robert T.} and Barbara Alksninis and Andrea Knoll and Keszler, {Mary L.} and Leach, {Teresa M.} and McGowan, {Elisabeth C.} and Watson, {Victoria E.} and Newman, {Nancy S.} and Siner, {Bonnie S.} and Elizabeth Roth and Angelia Williams and Poindexter, {Brenda B.} and Kurt Schibler and Cahill, {K. Tanya E.} and Cathy Grisby and Kristin Kirker and Sara Stacey and Sandra Wuertz and Goldberg, {Ronald N.} and Goldstein, {Ricki F.} and Ashley, {Patricia L.} and Deesha Mago-Shah and Joanne Finkle and Fisher, {Kimberley A.} and Gustafson, {Kathryn E.} and Caitlin Stone and Laughon, {Matthew M.} and Janice Bernhardt and Janice Wereszczak and Jennifer Talbert and Alexandra Bentley and Laura Edwards and Ginger Rhodes-Ryan and Donna White and Carlton, {David P.} and Yvonne Loggins and Diane Bottcher and Carter, {Sheena L.} and Salathiel Kendrick-Allwood and LaRossa, {Maureen Mulligan} and Judith Laursen and Colleen Mackie and Amy Sanders and Gloria Smikle and Lynn Wineski and Bremer, {Andrew A.} and Higgins, {Rosemary D.} and Archer, {Stephanie Wilson} and Khan, {Amir M.} and Kennedy, {Kathleen A.} and Duncan, {Andrea F.} and Elizabeth Allain and Julie Arldt-McAlister and Fatima Boricha and Dempsey, {Allison G.} and Carmen Garcia and Hall, {Donna J.} and Janice John and Lillie, {M. Layne} and Karen Martin and McDavid, {Georgia E.} and McKee, {Shannon L.} and Michelle Poe and Kimberly Rennie and Tina Reddy and Shawna Rodgers and Sperry, {Daniel K.} and Wright, {Sharon L.} and Nelin, {Leif D.} and Slaughter, {Jonathan L.} and Jadcherla, {Sudarshan R.} and Christopher Timan and Patricia Luzader and Melanie Stein and Sullivan, {Rox Ann} and Helen Carey and Stephanie Burkhardt and Nelin, {Mary Ann} and Erna Clark and Kristi Small and Jacqueline McCool and Lindsay Pietruszewski and Jessica Purnell and Kyrstin Warnimont and Laura Marzec and Bethany Miller and Beckford, {Demi R.} and Hallie Baugher and Katelyn Levengood and Nancy Batterson and Jill Tonneman and Krystal Hay and Brittany DeSantis and Dennis Wallace and Auman, {Jeanette O{\textquoteright} Donnell} and Margaret Crawford and Jenna Gabrio and Newman, {Jamie E.} and Lindsay Parlberg and Zaterka-Baxter, {Kristin M.} and Stevenson, {David K.} and Ball, {M. Bethany} and Valerie Chock and Dona Bahmani and Barbara Bentley and DeAnda, {Maria Elena} and DeBattista, {Anne M.} and Beth Earhart and Huffman, {Lynne C.} and Krueger, {Casey E.} and Lucash, {Ryan E.} and Heather Taylor and Weiss, {Hali E.} and Namasivayam Ambalavanan and Bailey, {Kirstin J.} and Biasini, {Fred J.} and Chopko, {Stephanie A.} and Collins, {Monica V.} and Cosby, {Shirley S.} and Domnanovich, {Kristy A.} and Jno-Finn, {Chantel J.} and Morissa Ladinsky and Moses, {Mary Beth} and McNair, {Tara E.} and Phillips, {Vivien A.} and Julie Preskitt and Rector, {Richard V.} and Kimberlly Stringer and Sally Whitley and Chapman, {Sheree York} and Harmon, {Heidi M.} and Johnson, {Karen J.} and Schmelzel, {Mendi L.} and Walker, {Jacky R.} and Goeke, {Claire A.} and Faruqui, {Sarah E.} and Eastman, {Diane L.} and Baack, {Michelle L.} and Hogden, {Laurie A.} and Henning, {Megan M.} and Chelsey Elenkiwich and Megan Broadbent and {Van Muyden}, Sarah and Ohls, {Robin K.} and Lacy, {Conra Backstrom} and Beauman, {Sandra Sundquist} and Hanson, {Mary Ruffner} and Lowe, {Jean R.} and Elizabeth Kuan and Eichenwald, {Eric C.} and Barbara Schmidt and Haresh Kirpalani and Soraya Abbasi and Chaudhary, {Aasma S.} and Toni Mancini and Jonathan Snyder and Kristina Ziolkowski and Ronnie Guillet and Satyan Lakshminrusimha and Reynolds, {Anne Marie} and Jensen, {Rosemary L.} and Joan Merzbach and William Zorn and Osman Farooq and Myers, {Gary J.} and Mary Rowan and Diane Prinzing and Melissa Bowman and Scorsone, {Ann Marie} and Kyle Binion and Constance Orme and Premini Sabaratnam and Alison Kent and Rachel Jones and Elizabeth Boylin and Emily Li and Jennifer Kachelmeyer and McKee, {Kimberly G.} and Coleman, {Kelly R.} and Brenna Cavanaugh and Brion, {Luc P.} and Vasil, {Diana M.} and Adams, {Sally S.} and Frances Eubanks and McDougald, {E. Rebecca} and Lara Pavageau and Pollieanna Sepulveda and Alicia Guzman and Elizabeth Heyne and Lee, {Lizette E.} and Azucena Vera and Jillian Waterbury and Boatman, {Cathy Twell} and Yoder, {Bradley A.} and Mariana Baserga and Faix, {Roger G.} and Minton, {Stephen D.} and Sheffield, {Mark J.} and Rau, {Carrie A.} and Shawna Baker and Susan Christensen and Cunningham, {Sean D.} and Elmont, {Jennifer O.} and Becky Hall and Jensen, {Erika R.} and Loertscher, {Manndi C.} and Trisha Marchant and McGrath, {Kandace M.} and Mickelsen, {Hena G.} and Galina Morshedzadeh and Parry, {D. Melody} and Kelly Stout and Stuart, {Ashley L.} and Kimberlee Weaver-Lewis",

note = "Publisher Copyright: {\textcopyright} 2023, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.",

year = "2023",

month = nov,

doi = "10.1038/s41372-023-01729-x",

language = "English",

volume = "43",

pages = "1398--1405",

number = "11",

}

Green, CE, Tyson, JE, Heyne, RJ, Hintz, SR, Vohr, BR, Bann, CM, Das, A, Bell, EF, Debsareea, SB, Stephens, E, Gantz, MG, Petrie Huitema, CM, Johnson, KJ, Watterberg, KL, Mosquera, R, Peralta-Carcelen, M, Wilson-Costello, DE, Colaizy, TT, Maitre, NL, Merhar, SL, Adams-Chapman, I, Fuller, J, Hartley-McAndrew, ME, Malcolm, WF, Winter, S, Duncan, AF, Myer, GJ, Kicklighter, SD, Wyckoff, MH, DeMauro, SB, Hibbs, AM, Stoll, BJ, Carlo, WA, Van Meurs, KP, Rysavy, MA, Patel, RM, Sánchez, PJ, Laptook, AR, Cotten, CM, D’Angio, CT, Walsh, MC, Polin, RA, Keszler, M, Hensman, AM, Vieira, E, Pierre, LS, Burke, RT, Alksninis, B, Knoll, A, Keszler, ML, Leach, TM, McGowan, EC, Watson, VE, Newman, NS, Siner, BS, Roth, E, Williams, A, Poindexter, BB, Schibler, K, Cahill, KTE, Grisby, C, Kirker, K, Stacey, S, Wuertz, S, Goldberg, RN, Goldstein, RF, Ashley, PL, Mago-Shah, D, Finkle, J, Fisher, KA, Gustafson, KE, Stone, C, Laughon, MM, Bernhardt, J, Wereszczak, J, Talbert, J, Bentley, A, Edwards, L, Rhodes-Ryan, G, White, D, Carlton, DP, Loggins, Y, Bottcher, D, Carter, SL, Kendrick-Allwood, S, LaRossa, MM, Laursen, J, Mackie, C, Sanders, A, Smikle, G, Wineski, L, Bremer, AA, Higgins, RD, Archer, SW, Khan, AM, Kennedy, KA, Duncan, AF, Allain, E, Arldt-McAlister, J, Boricha, F, Dempsey, AG, Garcia, C, Hall, DJ, John, J, Lillie, ML, Martin, K, McDavid, GE, McKee, SL, Poe, M, Rennie, K, Reddy, T, Rodgers, S, Sperry, DK, Wright, SL, Nelin, LD, Slaughter, JL, Jadcherla, SR, Timan, C, Luzader, P, Stein, M, Sullivan, RA, Carey, H, Burkhardt, S, Nelin, MA, Clark, E, Small, K, McCool, J, Pietruszewski, L, Purnell, J, Warnimont, K, Marzec, L, Miller, B, Beckford, DR, Baugher, H, Levengood, K, Batterson, N, Tonneman, J, Hay, K, DeSantis, B, Wallace, D, Auman, JOD, Crawford, M, Gabrio, J, Newman, JE, Parlberg, L, Zaterka-Baxter, KM, Stevenson, DK, Ball, MB, Chock, V, Bahmani, D, Bentley, B, DeAnda, ME, DeBattista, AM, Earhart, B, Huffman, LC, Krueger, CE, Lucash, RE, Taylor, H, Weiss, HE, Ambalavanan, N, Bailey, KJ, Biasini, FJ, Chopko, SA, Collins, MV, Cosby, SS, Domnanovich, KA, Jno-Finn, CJ, Ladinsky, M, Moses, MB, McNair, TE, Phillips, VA, Preskitt, J, Rector, RV, Stringer, K, Whitley, S, Chapman, SY, Harmon, HM, Johnson, KJ, Schmelzel, ML, Walker, JR, Goeke, CA, Faruqui, SE, Eastman, DL, Baack, ML, Hogden, LA, Henning, MM, Elenkiwich, C, Broadbent, M, Van Muyden, S, Ohls, RK, Lacy, CB, Beauman, SS, Hanson, MR, Lowe, JR, Kuan, E, Eichenwald, EC, Schmidt, B, Kirpalani, H, Abbasi, S, Chaudhary, AS, Mancini, T, Snyder, J, Ziolkowski, K, Guillet, R, Lakshminrusimha, S, Reynolds, AM, Jensen, RL, Merzbach, J, Zorn, W, Farooq, O, Myers, GJ, Rowan, M, Prinzing, D, Bowman, M, Scorsone, AM, Binion, K, Orme, C, Sabaratnam, P, Kent, A, Jones, R, Boylin, E, Li, E, Kachelmeyer, J, McKee, KG, Coleman, KR, Cavanaugh, B, Brion, LP, Vasil, DM, Adams, SS, Eubanks, F, McDougald, ER, Pavageau, L, Sepulveda, P, Guzman, A, Heyne, E, Lee, LE, Vera, A, Waterbury, J, Boatman, CT, Yoder, BA, Baserga, M, Faix, RG, Minton, SD, Sheffield, MJ, Rau, CA, Baker, S, Christensen, S, Cunningham, SD, Elmont, JO, Hall, B, Jensen, ER, Loertscher, MC, Marchant, T, McGrath, KM, Mickelsen, HG, Morshedzadeh, G, Parry, DM, Stout, K, Stuart, AL & Weaver-Lewis, K 2023, 'Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study', Journal of Perinatology, vol. 43, no. 11, pp. 1398-1405. https://doi.org/10.1038/s41372-023-01729-x

TY - JOUR

T1 - Use of term reference infants in assessing the developmental outcome of extremely preterm infants

T2 - lessons learned in a multicenter study

AU - Green, Charles E.

AU - Tyson, Jon E.

AU - Heyne, Roy J.

AU - Hintz, Susan R.

AU - Vohr, Betty R.

AU - Bann, Carla M.

AU - Das, Abhik

AU - Bell, Edward F.

AU - Debsareea, Sana Boral

AU - Stephens, Emily

AU - Gantz, Marie G.

AU - Petrie Huitema, Carolyn M.

AU - Johnson, Karen J.

AU - Watterberg, Kristi L.

AU - Mosquera, Ricardo

AU - Peralta-Carcelen, Myriam

AU - Wilson-Costello, Deanne E.

AU - Colaizy, Tarah T.

AU - Maitre, Nathalie L.

AU - Merhar, Stephanie L.

AU - Adams-Chapman, Ira

AU - Fuller, Janell

AU - Hartley-McAndrew, Michelle E.

AU - Malcolm, William F.

AU - Winter, Sarah

AU - Duncan, Andrea F.

AU - Myer, Gary J.

AU - Kicklighter, Stephen D.

AU - Wyckoff, Myra H.

AU - DeMauro, Sara B.

AU - Hibbs, Anna Maria

AU - Stoll, Barbara J.

AU - Carlo, Waldemar A.

AU - Van Meurs, Krisa P.

AU - Rysavy, Matthew A.

AU - Patel, Ravi M.

AU - Sánchez, Pablo J.

AU - Laptook, Abbot R.

AU - Cotten, C. Michael

AU - D’Angio, Carl T.

AU - Walsh, Michele C.

AU - Polin, Richard A.

AU - Keszler, Martin

AU - Hensman, Angelita M.

AU - Vieira, Elisa

AU - Pierre, Lucille St

AU - Burke, Robert T.

AU - Alksninis, Barbara

AU - Knoll, Andrea

AU - Keszler, Mary L.

AU - Leach, Teresa M.

AU - McGowan, Elisabeth C.

AU - Watson, Victoria E.

AU - Newman, Nancy S.

AU - Siner, Bonnie S.

AU - Roth, Elizabeth

AU - Williams, Angelia

AU - Poindexter, Brenda B.

AU - Schibler, Kurt

AU - Cahill, K. Tanya E.

AU - Grisby, Cathy

AU - Kirker, Kristin

AU - Stacey, Sara

AU - Wuertz, Sandra

AU - Goldberg, Ronald N.

AU - Goldstein, Ricki F.

AU - Ashley, Patricia L.

AU - Mago-Shah, Deesha

AU - Finkle, Joanne

AU - Fisher, Kimberley A.

AU - Gustafson, Kathryn E.

AU - Stone, Caitlin

AU - Laughon, Matthew M.

AU - Bernhardt, Janice

AU - Wereszczak, Janice

AU - Talbert, Jennifer

AU - Bentley, Alexandra

AU - Edwards, Laura

AU - Rhodes-Ryan, Ginger

AU - White, Donna

AU - Carlton, David P.

AU - Loggins, Yvonne

AU - Bottcher, Diane

AU - Carter, Sheena L.

AU - Kendrick-Allwood, Salathiel

AU - LaRossa, Maureen Mulligan

AU - Laursen, Judith

AU - Mackie, Colleen

AU - Sanders, Amy

AU - Smikle, Gloria

AU - Wineski, Lynn

AU - Bremer, Andrew A.

AU - Higgins, Rosemary D.

AU - Archer, Stephanie Wilson

AU - Khan, Amir M.

AU - Kennedy, Kathleen A.

AU - Duncan, Andrea F.

AU - Allain, Elizabeth

AU - Arldt-McAlister, Julie

AU - Boricha, Fatima

AU - Dempsey, Allison G.

AU - Garcia, Carmen

AU - Hall, Donna J.

AU - John, Janice

AU - Lillie, M. Layne

AU - Martin, Karen

AU - McDavid, Georgia E.

AU - McKee, Shannon L.

AU - Poe, Michelle

AU - Rennie, Kimberly

AU - Reddy, Tina

AU - Rodgers, Shawna

AU - Sperry, Daniel K.

AU - Wright, Sharon L.

AU - Nelin, Leif D.

AU - Slaughter, Jonathan L.

AU - Jadcherla, Sudarshan R.

AU - Timan, Christopher

AU - Luzader, Patricia

AU - Stein, Melanie

AU - Sullivan, Rox Ann

AU - Carey, Helen

AU - Burkhardt, Stephanie

AU - Nelin, Mary Ann

AU - Clark, Erna

AU - Small, Kristi

AU - McCool, Jacqueline

AU - Pietruszewski, Lindsay

AU - Purnell, Jessica

AU - Warnimont, Kyrstin

AU - Marzec, Laura

AU - Miller, Bethany

AU - Beckford, Demi R.

AU - Baugher, Hallie

AU - Levengood, Katelyn

AU - Batterson, Nancy

AU - Tonneman, Jill

AU - Hay, Krystal

AU - DeSantis, Brittany

AU - Wallace, Dennis

AU - Auman, Jeanette O’ Donnell

AU - Crawford, Margaret

AU - Gabrio, Jenna

AU - Newman, Jamie E.

AU - Parlberg, Lindsay

AU - Zaterka-Baxter, Kristin M.

AU - Stevenson, David K.

AU - Ball, M. Bethany

AU - Chock, Valerie

AU - Bahmani, Dona

AU - Bentley, Barbara

AU - DeAnda, Maria Elena

AU - DeBattista, Anne M.

AU - Earhart, Beth

AU - Huffman, Lynne C.

AU - Krueger, Casey E.

AU - Lucash, Ryan E.

AU - Taylor, Heather

AU - Weiss, Hali E.

AU - Ambalavanan, Namasivayam

AU - Bailey, Kirstin J.

AU - Biasini, Fred J.

AU - Chopko, Stephanie A.

AU - Collins, Monica V.

AU - Cosby, Shirley S.

AU - Domnanovich, Kristy A.

AU - Jno-Finn, Chantel J.

AU - Ladinsky, Morissa

AU - Moses, Mary Beth

AU - McNair, Tara E.

AU - Phillips, Vivien A.

AU - Preskitt, Julie

AU - Rector, Richard V.

AU - Stringer, Kimberlly

AU - Whitley, Sally

AU - Chapman, Sheree York

AU - Harmon, Heidi M.

AU - Johnson, Karen J.

AU - Schmelzel, Mendi L.

AU - Walker, Jacky R.

AU - Goeke, Claire A.

AU - Faruqui, Sarah E.

AU - Eastman, Diane L.

AU - Baack, Michelle L.

AU - Hogden, Laurie A.

AU - Henning, Megan M.

AU - Elenkiwich, Chelsey

AU - Broadbent, Megan

AU - Van Muyden, Sarah

AU - Ohls, Robin K.

AU - Lacy, Conra Backstrom

AU - Beauman, Sandra Sundquist

AU - Hanson, Mary Ruffner

AU - Lowe, Jean R.

AU - Kuan, Elizabeth

AU - Eichenwald, Eric C.

AU - Schmidt, Barbara

AU - Kirpalani, Haresh

AU - Abbasi, Soraya

AU - Chaudhary, Aasma S.

AU - Mancini, Toni

AU - Snyder, Jonathan

AU - Ziolkowski, Kristina

AU - Guillet, Ronnie

AU - Lakshminrusimha, Satyan

AU - Reynolds, Anne Marie

AU - Jensen, Rosemary L.

AU - Merzbach, Joan

AU - Zorn, William

AU - Farooq, Osman

AU - Myers, Gary J.

AU - Rowan, Mary

AU - Prinzing, Diane

AU - Bowman, Melissa

AU - Scorsone, Ann Marie

AU - Binion, Kyle

AU - Orme, Constance

AU - Sabaratnam, Premini

AU - Kent, Alison

AU - Jones, Rachel

AU - Boylin, Elizabeth

AU - Li, Emily

AU - Kachelmeyer, Jennifer

AU - McKee, Kimberly G.

AU - Coleman, Kelly R.

AU - Cavanaugh, Brenna

AU - Brion, Luc P.

AU - Vasil, Diana M.

AU - Adams, Sally S.

AU - Eubanks, Frances

AU - McDougald, E. Rebecca

AU - Pavageau, Lara

AU - Sepulveda, Pollieanna

AU - Guzman, Alicia

AU - Heyne, Elizabeth

AU - Lee, Lizette E.

AU - Vera, Azucena

AU - Waterbury, Jillian

AU - Boatman, Cathy Twell

AU - Yoder, Bradley A.

AU - Baserga, Mariana

AU - Faix, Roger G.

AU - Minton, Stephen D.

AU - Sheffield, Mark J.

AU - Rau, Carrie A.

AU - Baker, Shawna

AU - Christensen, Susan

AU - Cunningham, Sean D.

AU - Elmont, Jennifer O.

AU - Hall, Becky

AU - Jensen, Erika R.

AU - Loertscher, Manndi C.

AU - Marchant, Trisha

AU - McGrath, Kandace M.

AU - Mickelsen, Hena G.

AU - Morshedzadeh, Galina

AU - Parry, D. Melody

AU - Stout, Kelly

AU - Stuart, Ashley L.

AU - Weaver-Lewis, Kimberlee

PY - 2023/11

Y1 - 2023/11

N2 - Objective: Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. Study design: Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age. Results: We assessed 1452 EP infants and 183 TR infants. TR-based thresholds showed higher overall EP impairment than Bayley norm-based thresholds (O.R. = 1.86; [95% CI 1.56–2.23], especially for severe impairment (36% vs. 24%; p ≤ 0.001). Difficulty recruiting TR patients at 2 years extended the study by 14 months and affected their demographics. Conclusion: Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. ClinicalTrials.gov ID: Term Reference (under the Generic Database Study): NCT00063063.

AB - Objective: Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. Study design: Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age. Results: We assessed 1452 EP infants and 183 TR infants. TR-based thresholds showed higher overall EP impairment than Bayley norm-based thresholds (O.R. = 1.86; [95% CI 1.56–2.23], especially for severe impairment (36% vs. 24%; p ≤ 0.001). Difficulty recruiting TR patients at 2 years extended the study by 14 months and affected their demographics. Conclusion: Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. ClinicalTrials.gov ID: Term Reference (under the Generic Database Study): NCT00063063.

UR - http://www.scopus.com/inward/record.url?scp=85166767123&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85166767123&partnerID=8YFLogxK

U2 - 10.1038/s41372-023-01729-x

DO - 10.1038/s41372-023-01729-x

M3 - Article

C2 - 37542155

AN - SCOPUS:85166767123

SN - 0743-8346

VL - 43

SP - 1398

EP - 1405

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 11

ER -

Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study

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