Using anesthetics and analgesics in experimental traumatic brain injury

Rachel K. Rowe, Jordan L. Harrison, Theresa C. Thomas, James R. Pauly, P. David Adelson, Jonathan Lifshitz

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Valid modeling of traumatic brain injury (TBI) requires accurate replication of both the mechanical forces that cause the primary injury and the conditions that lead to secondary injuries observed in human patients. The use of animals in TBI research is justified by the lack of in vitro or computer models that can sufficiently replicate the complex pathological processes involved. Measures to reduce nociception and distress must be implemented, but the administration of anesthetics and analgesics can influence TBI outcomes, threatening the validity of the research. In this review, the authors present evidence for the interference of anesthetics and analgesics in the natural course of brain injury in animal models of TBI. They suggest that drugs should be selected for or excluded from experimental TBI protocols on the basis of IACUC-approved experimental objectives in order to protect animal welfare and preserve the validity of TBI models.

Original languageEnglish
Pages (from-to)286-291
Number of pages6
JournalLab Animal
Issue number8
StatePublished - Aug 2013

ASJC Scopus subject areas

  • Animal Science and Zoology
  • General Veterinary


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