Using optical fibers with different modes to improve the signal-to-noise ratio of diffuse correlation spectroscopy flow-oximeter measurements

Lian He; Yu Lin; Yu Shang; Brent J. Shelton; Guoqiang Yu

doi:10.1117/1.JBO.18.3.037001

Using optical fibers with different modes to improve the signal-to-noise ratio of diffuse correlation spectroscopy flow-oximeter measurements

Lian He, Yu Lin, Yu Shang, Brent J. Shelton, Guoqiang Yu

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The dual-wavelength diffuse correlation spectroscopy (DCS) flow-oximeter is an emerging technique enabling simultaneous measurements of blood flow and blood oxygenation changes in deep tissues. High signal-to-noise ratio (SNR) is crucial when applying DCS technologies in the study of human tissues where the detected signals are usually very weak. In this study, single-mode, few-mode, and multimode fibers are compared to explore the possibility of improving the SNR of DCS flow-oximeter measurements. Experiments on liquid phantom solutions and in vivo muscle tissues show only slight improvements in flow measurements when using the fewmode fiber compared with using the single-mode fiber. However, light intensities detected by the few-mode and multimode fibers are increased, leading to significant SNR improvements in detections of phantom optical property and tissue blood oxygenation. The outcomes from this study provide useful guidance for the selection of optical fibers to improve DCS flow-oximeter measurements.

Original language	English
Article number	037001
Journal	Journal of Biomedical Optics
Volume	18
Issue number	3
DOIs	https://doi.org/10.1117/1.JBO.18.3.037001
State	Published - Mar 2013

Bibliographical note

Funding Information:
This study was supported partially by the grants R01 CA149274, R21 AR062356, and UL1RR033173 from National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH.

Keywords

blood flow
blood oxygenation
diffuse correlation spectroscopy
optical fiber mode
signal-to-noise ratio

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

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10.1117/1.JBO.18.3.037001

Cite this

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title = "Using optical fibers with different modes to improve the signal-to-noise ratio of diffuse correlation spectroscopy flow-oximeter measurements",

abstract = "The dual-wavelength diffuse correlation spectroscopy (DCS) flow-oximeter is an emerging technique enabling simultaneous measurements of blood flow and blood oxygenation changes in deep tissues. High signal-to-noise ratio (SNR) is crucial when applying DCS technologies in the study of human tissues where the detected signals are usually very weak. In this study, single-mode, few-mode, and multimode fibers are compared to explore the possibility of improving the SNR of DCS flow-oximeter measurements. Experiments on liquid phantom solutions and in vivo muscle tissues show only slight improvements in flow measurements when using the fewmode fiber compared with using the single-mode fiber. However, light intensities detected by the few-mode and multimode fibers are increased, leading to significant SNR improvements in detections of phantom optical property and tissue blood oxygenation. The outcomes from this study provide useful guidance for the selection of optical fibers to improve DCS flow-oximeter measurements.",

keywords = "blood flow, blood oxygenation, diffuse correlation spectroscopy, optical fiber mode, signal-to-noise ratio",

author = "Lian He and Yu Lin and Yu Shang and Shelton, {Brent J.} and Guoqiang Yu",

note = "Funding Information: This study was supported partially by the grants R01 CA149274, R21 AR062356, and UL1RR033173 from National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH.",

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AU - Shang, Yu

AU - Shelton, Brent J.

AU - Yu, Guoqiang

N1 - Funding Information: This study was supported partially by the grants R01 CA149274, R21 AR062356, and UL1RR033173 from National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH.

PY - 2013/3

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N2 - The dual-wavelength diffuse correlation spectroscopy (DCS) flow-oximeter is an emerging technique enabling simultaneous measurements of blood flow and blood oxygenation changes in deep tissues. High signal-to-noise ratio (SNR) is crucial when applying DCS technologies in the study of human tissues where the detected signals are usually very weak. In this study, single-mode, few-mode, and multimode fibers are compared to explore the possibility of improving the SNR of DCS flow-oximeter measurements. Experiments on liquid phantom solutions and in vivo muscle tissues show only slight improvements in flow measurements when using the fewmode fiber compared with using the single-mode fiber. However, light intensities detected by the few-mode and multimode fibers are increased, leading to significant SNR improvements in detections of phantom optical property and tissue blood oxygenation. The outcomes from this study provide useful guidance for the selection of optical fibers to improve DCS flow-oximeter measurements.

AB - The dual-wavelength diffuse correlation spectroscopy (DCS) flow-oximeter is an emerging technique enabling simultaneous measurements of blood flow and blood oxygenation changes in deep tissues. High signal-to-noise ratio (SNR) is crucial when applying DCS technologies in the study of human tissues where the detected signals are usually very weak. In this study, single-mode, few-mode, and multimode fibers are compared to explore the possibility of improving the SNR of DCS flow-oximeter measurements. Experiments on liquid phantom solutions and in vivo muscle tissues show only slight improvements in flow measurements when using the fewmode fiber compared with using the single-mode fiber. However, light intensities detected by the few-mode and multimode fibers are increased, leading to significant SNR improvements in detections of phantom optical property and tissue blood oxygenation. The outcomes from this study provide useful guidance for the selection of optical fibers to improve DCS flow-oximeter measurements.

KW - blood flow

KW - blood oxygenation

KW - diffuse correlation spectroscopy

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KW - signal-to-noise ratio

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Using optical fibers with different modes to improve the signal-to-noise ratio of diffuse correlation spectroscopy flow-oximeter measurements

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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