Using preclinical models to understand the neural basis of negative urgency

Michael T. Bardo, Virginia G. Weiss, George V. Rebec

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


Negative urgency is a facet of impulsivity that is known to be associated with problematic substance use, as well as a host of other health-related negative outcomes. The urgency, premediation (lack of), perseverance (lack of), sensation seeking (UPPS) scale is used to measure negative urgency in humans. Recent evidence indicates that high and low negative urgency subjects respond differently on a reward omission task using monetary incentives. Following omission of an expected reward, high-urgency subjects are more frustrated and display greater impulsive responding compared to low-urgency subjects. This task has also been used in rats to investigate the neurobiology of negative urgency. Converging evidence now indicates that a neural system involving interconnections between the prefrontal cortex and amygdala may play a key role in individual differences in negative urgency. This work may inform prevention scientists and practitioners implementing drug abuse prevention and treatment interventions.

Original languageEnglish
Title of host publicationNeurobiology of Abnormal Emotion and Motivated Behaviors
Subtitle of host publicationIntegrating Animal and Human Research
Number of pages19
ISBN (Electronic)9780128136935
StatePublished - Jan 1 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc. All rights reserved.


  • Amygdala
  • Drug abuse
  • Negative urgency
  • Prefrontal cortex
  • Reward omission

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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