Utilization of a nitrenium ion cyclization in a synthesis of a photoactive prostaglandin, 17-(4-azido-2-hydroxyphenyl)-18,19,20-trinorprostaglandin F2/ga

E. Kurt Dolence, Hiroyuki Morita, David S. Watt, Tony Fitz

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A nitrenium ion cyclization provided access to a suitably substituted arylpropionic ester needed in the synthesis of a potential prostaglandin photoaffinity probe, 17-(4-azido-2-hydroxyphenyl)-18,19,20-trinorprostaglandin F2α using the Corey synthesis.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalTetrahedron Letters
Volume28
Issue number1
DOIs
StatePublished - 1987

Bibliographical note

Funding Information:
Acknowledgement. We thank the National Institutes generous financial support, the Upjohn Company for the Midwest Center for Mass Spectrometry for exact of Health (HL 20780) for a gift of chemicals, and mass spectra.

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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