Utilization of a nitrenium ion cyclization in a synthesis of a photoactive prostaglandin, 17-(4-azido-2-hydroxyphenyl)-18,19,20-trinorprostaglandin F2/ga

  • E. Kurt Dolence
  • , Hiroyuki Morita
  • , David S. Watt
  • , Tony Fitz

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A nitrenium ion cyclization provided access to a suitably substituted arylpropionic ester needed in the synthesis of a potential prostaglandin photoaffinity probe, 17-(4-azido-2-hydroxyphenyl)-18,19,20-trinorprostaglandin F2α using the Corey synthesis.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalTetrahedron Letters
Volume28
Issue number1
DOIs
StatePublished - 1987

Bibliographical note

Funding Information:
Acknowledgement. We thank the National Institutes generous financial support, the Upjohn Company for the Midwest Center for Mass Spectrometry for exact of Health (HL 20780) for a gift of chemicals, and mass spectra.

Funding

Acknowledgement. We thank the National Institutes generous financial support, the Upjohn Company for the Midwest Center for Mass Spectrometry for exact of Health (HL 20780) for a gift of chemicals, and mass spectra.

FundersFunder number
National Institutes of Health (NIH)
Upjohn Company for the Midwest Center for Mass Spectrometry for exact of HealthHL 20780

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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