Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review

Antonia van Kampen; Jordan E. Morningstar; Guillaume Goudot; Neil Ingels; Jonathan F. Wenk; Yasufumi Nagata; Koushiar M. Yaghoubian; Russell A. Norris; Michael A. Borger; Serguei Melnitchouk; Robert A. Levine; Morten O. Jensen

doi:10.3390/bioengineering10050601

Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review

Antonia van Kampen, Jordan E. Morningstar, Guillaume Goudot, Neil Ingels, Jonathan F. Wenk, Yasufumi Nagata, Koushiar M. Yaghoubian, Russell A. Norris, Michael A. Borger, Serguei Melnitchouk, Robert A. Levine, Morten O. Jensen

Research output: Contribution to journal › Review article › peer-review

Abstract

The geometrical details and biomechanical relationships of the mitral valve–left ventricular apparatus are very complex and have posed as an area of research interest for decades. These characteristics play a major role in identifying and perfecting the optimal approaches to treat diseases of this system when the restoration of biomechanical and mechano-biological conditions becomes the main target. Over the years, engineering approaches have helped to revolutionize the field in this regard. Furthermore, advanced modelling modalities have contributed greatly to the development of novel devices and less invasive strategies. This article provides an overview and narrative of the evolution of mitral valve therapy with special focus on two diseases frequently encountered by cardiac surgeons and interventional cardiologists: ischemic and degenerative mitral regurgitation.

Original language	English
Article number	601
Journal	Bioengineering
Volume	10
Issue number	5
DOIs	https://doi.org/10.3390/bioengineering10050601
State	Published - May 2023

Bibliographical note

Funding Information:
AVK is supported by the American Heart Association (Postdoctoral Fellowship Award). JEM is supported by the National Institutes of Health (1F31HL167482). MOJ and NE are supported by the National Institutes of Health (1R15HL145585) and the Arkansas Research Alliance. JFW is supported by the National Institutes of Health (1R15HL145585). RAN is supported by the National Institutes of Health (1R01HL131645, 1R01HL149696, 1R01GM10344) and the American Heart Association (19TPA34850095, 17CSA33590067). RAL and KMY are supported by the National Institutes of Health (1R01HL141917) and the American Heart Association (22TPA963793).

Publisher Copyright:
© 2023 by the authors.

Keywords

biomechanics
computational modelling
ex vivo modelling
force measurements
mechanical engineering
mitral valve
mitral valve simulation
subvalvular apparatus

ASJC Scopus subject areas

Bioengineering

Access to Document

10.3390/bioengineering10050601

Cite this

van Kampen, A., Morningstar, J. E., Goudot, G., Ingels, N., Wenk, J. F., Nagata, Y., Yaghoubian, K. M., Norris, R. A., Borger, M. A., Melnitchouk, S., Levine, R. A., & Jensen, M. O. (2023). Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review. Bioengineering, 10(5), Article 601. https://doi.org/10.3390/bioengineering10050601

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title = "Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review",

abstract = "The geometrical details and biomechanical relationships of the mitral valve–left ventricular apparatus are very complex and have posed as an area of research interest for decades. These characteristics play a major role in identifying and perfecting the optimal approaches to treat diseases of this system when the restoration of biomechanical and mechano-biological conditions becomes the main target. Over the years, engineering approaches have helped to revolutionize the field in this regard. Furthermore, advanced modelling modalities have contributed greatly to the development of novel devices and less invasive strategies. This article provides an overview and narrative of the evolution of mitral valve therapy with special focus on two diseases frequently encountered by cardiac surgeons and interventional cardiologists: ischemic and degenerative mitral regurgitation.",

keywords = "biomechanics, computational modelling, ex vivo modelling, force measurements, mechanical engineering, mitral valve, mitral valve simulation, subvalvular apparatus",

author = "{van Kampen}, Antonia and Morningstar, {Jordan E.} and Guillaume Goudot and Neil Ingels and Wenk, {Jonathan F.} and Yasufumi Nagata and Yaghoubian, {Koushiar M.} and Norris, {Russell A.} and Borger, {Michael A.} and Serguei Melnitchouk and Levine, {Robert A.} and Jensen, {Morten O.}",

note = "Funding Information: AVK is supported by the American Heart Association (Postdoctoral Fellowship Award). JEM is supported by the National Institutes of Health (1F31HL167482). MOJ and NE are supported by the National Institutes of Health (1R15HL145585) and the Arkansas Research Alliance. JFW is supported by the National Institutes of Health (1R15HL145585). RAN is supported by the National Institutes of Health (1R01HL131645, 1R01HL149696, 1R01GM10344) and the American Heart Association (19TPA34850095, 17CSA33590067). RAL and KMY are supported by the National Institutes of Health (1R01HL141917) and the American Heart Association (22TPA963793). Publisher Copyright: {\textcopyright} 2023 by the authors.",

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van Kampen, A, Morningstar, JE, Goudot, G, Ingels, N, Wenk, JF, Nagata, Y, Yaghoubian, KM, Norris, RA, Borger, MA, Melnitchouk, S, Levine, RA & Jensen, MO 2023, 'Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review', Bioengineering, vol. 10, no. 5, 601. https://doi.org/10.3390/bioengineering10050601

Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review. / van Kampen, Antonia; Morningstar, Jordan E.; Goudot, Guillaume et al.
In: Bioengineering, Vol. 10, No. 5, 601, 05.2023.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies

T2 - A Comprehensive Review

AU - van Kampen, Antonia

AU - Morningstar, Jordan E.

AU - Goudot, Guillaume

AU - Ingels, Neil

AU - Wenk, Jonathan F.

AU - Nagata, Yasufumi

AU - Yaghoubian, Koushiar M.

AU - Norris, Russell A.

AU - Borger, Michael A.

AU - Melnitchouk, Serguei

AU - Levine, Robert A.

AU - Jensen, Morten O.

N1 - Funding Information: AVK is supported by the American Heart Association (Postdoctoral Fellowship Award). JEM is supported by the National Institutes of Health (1F31HL167482). MOJ and NE are supported by the National Institutes of Health (1R15HL145585) and the Arkansas Research Alliance. JFW is supported by the National Institutes of Health (1R15HL145585). RAN is supported by the National Institutes of Health (1R01HL131645, 1R01HL149696, 1R01GM10344) and the American Heart Association (19TPA34850095, 17CSA33590067). RAL and KMY are supported by the National Institutes of Health (1R01HL141917) and the American Heart Association (22TPA963793). Publisher Copyright: © 2023 by the authors.

PY - 2023/5

Y1 - 2023/5

N2 - The geometrical details and biomechanical relationships of the mitral valve–left ventricular apparatus are very complex and have posed as an area of research interest for decades. These characteristics play a major role in identifying and perfecting the optimal approaches to treat diseases of this system when the restoration of biomechanical and mechano-biological conditions becomes the main target. Over the years, engineering approaches have helped to revolutionize the field in this regard. Furthermore, advanced modelling modalities have contributed greatly to the development of novel devices and less invasive strategies. This article provides an overview and narrative of the evolution of mitral valve therapy with special focus on two diseases frequently encountered by cardiac surgeons and interventional cardiologists: ischemic and degenerative mitral regurgitation.

AB - The geometrical details and biomechanical relationships of the mitral valve–left ventricular apparatus are very complex and have posed as an area of research interest for decades. These characteristics play a major role in identifying and perfecting the optimal approaches to treat diseases of this system when the restoration of biomechanical and mechano-biological conditions becomes the main target. Over the years, engineering approaches have helped to revolutionize the field in this regard. Furthermore, advanced modelling modalities have contributed greatly to the development of novel devices and less invasive strategies. This article provides an overview and narrative of the evolution of mitral valve therapy with special focus on two diseases frequently encountered by cardiac surgeons and interventional cardiologists: ischemic and degenerative mitral regurgitation.

KW - biomechanics

KW - computational modelling

KW - ex vivo modelling

KW - force measurements

KW - mechanical engineering

KW - mitral valve

KW - mitral valve simulation

KW - subvalvular apparatus

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DO - 10.3390/bioengineering10050601

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JO - Bioengineering

JF - Bioengineering

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Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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