UV radiation and the skin

John D'Orazio, Stuart Jarrett, Alexandra Amaro-Ortiz, Timothy Scott

Research output: Contribution to journalReview articlepeer-review

1196 Scopus citations


UV radiation (UV) is classified as a -complete carcinogen because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter. In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other environmentally-influenced skin disorders. However, UV also benefits human health by mediating natural synthesis of vitamin D and endorphins in the skin, therefore UV has complex and mixed effects on human health. Nonetheless, excessive exposure to UV carries profound health risks, including atrophy, pigmentary changes, wrinkling and malignancy. UV is epidemiologically and molecularly linked to the three most common types of skin cancer, basal cell carcinoma, squamous cell carcinoma and malignant melanoma, which together affect more than a million Americans annually. Genetic factors also influence risk of UV-mediated skin disease. Polymorphisms of the melanocortin 1 receptor (MC1R) gene, in particular, correlate with fairness of skin, UV sensitivity, and enhanced cancer risk. We are interested in developing UV-protective approaches based on a detailed understanding of molecular events that occur after UV exposure, focusing particularly on epidermal melanization and the role of the MC1R in genome maintenance.

Original languageEnglish
Pages (from-to)12222-12248
Number of pages27
JournalInternational Journal of Molecular Sciences
Issue number6
StatePublished - Jun 2013


  • Cancer
  • Carcinogenesis
  • Melanin
  • Melanocortin 1 receptor
  • Mutagenesis
  • Pigmentation
  • Skin
  • Ultraviolet radiation

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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