Vaccines for lung cancer

Edward A. Hirschowitz, David M. Hiestand, John R. Yannelli

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Immunotherapy is based on the knowledge that the immune system can distinguish cancerous cells from normal cells. Conceptually, this is an attractive adjuvant approach because it is highly specific and can deal with disseminated disease with minimal impact on normal tissues. In this review, we focus on strategies that use host immune machinery to generate anti-tumor effects, known as active immunotherapy. Proof of principle in lung cancer is now well established in clinical trials, although no superior approach has been defined and therapeutic efficacy remains unknown. In this review, we discuss rationale, biological theory, application, and clinical implementation to date.

Original languageEnglish
Pages (from-to)93-104
Number of pages12
JournalJournal of Thoracic Oncology
Volume1
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Immunotherapy
  • Lung cancer
  • Vaccine

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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