Vaginal progesterone reduces the risk of preterm birth and adverse perinatal outcomes in singleton gestations with a midtrimester sonographic short cervix (≤25 mm): an updated individual patient data meta-analysis

Roberto Romero; Agustin Conde-Agudelo; Eduardo da Fonseca; John M. O'Brien; George W. Creasy; Sonia S. Hassan; Kypros H. Nicolaides

doi:10.1016/j.ajog.2025.03.013

Vaginal progesterone reduces the risk of preterm birth and adverse perinatal outcomes in singleton gestations with a midtrimester sonographic short cervix (≤25 mm): an updated individual patient data meta-analysis

Roberto Romero
, Agustin Conde-Agudelo
, Eduardo da Fonseca
, John M. O'Brien
, George W. Creasy
, Sonia S. Hassan
, Kypros H. Nicolaides

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Original language	English
Pages (from-to)	e1-e5
Journal	American Journal of Obstetrics and Gynecology
Volume	233
Issue number	1
DOIs	https://doi.org/10.1016/j.ajog.2025.03.013
State	Published - Jul 2025

Funding

This work was supported, in part, by the Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services (NICHD/NIH/DHHS); and, in part, by federal funds from NICHD/NIH/DHHS (Contract No. HHSN275201300006C). The funder had no role in the design or conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review or approval of the manuscript or the decision to submit the manuscript for publication.

Funders	Funder number
NIH National Institute of Child Health and Human Development National Center for Medical Rehabilitation Research
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health (NIH)
Division of Intramural Research
U.S. Department of Health and Human Services	HHSN275201300006C

ASJC Scopus subject areas

Obstetrics and Gynecology

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Romero, R., Conde-Agudelo, A., da Fonseca, E., O'Brien, J. M., Creasy, G. W., Hassan, S. S., & Nicolaides, K. H. (2025). Vaginal progesterone reduces the risk of preterm birth and adverse perinatal outcomes in singleton gestations with a midtrimester sonographic short cervix (≤25 mm): an updated individual patient data meta-analysis. American Journal of Obstetrics and Gynecology, 233(1), e1-e5. https://doi.org/10.1016/j.ajog.2025.03.013

Romero, Roberto ; Conde-Agudelo, Agustin ; da Fonseca, Eduardo et al. / Vaginal progesterone reduces the risk of preterm birth and adverse perinatal outcomes in singleton gestations with a midtrimester sonographic short cervix (≤25 mm) : an updated individual patient data meta-analysis. In: American Journal of Obstetrics and Gynecology. 2025 ; Vol. 233, No. 1. pp. e1-e5.

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Romero, R, Conde-Agudelo, A, da Fonseca, E, O'Brien, JM, Creasy, GW, Hassan, SS & Nicolaides, KH 2025, 'Vaginal progesterone reduces the risk of preterm birth and adverse perinatal outcomes in singleton gestations with a midtrimester sonographic short cervix (≤25 mm): an updated individual patient data meta-analysis', American Journal of Obstetrics and Gynecology, vol. 233, no. 1, pp. e1-e5. https://doi.org/10.1016/j.ajog.2025.03.013

Vaginal progesterone reduces the risk of preterm birth and adverse perinatal outcomes in singleton gestations with a midtrimester sonographic short cervix (≤25 mm): an updated individual patient data meta-analysis. / Romero, Roberto; Conde-Agudelo, Agustin; da Fonseca, Eduardo et al.
In: American Journal of Obstetrics and Gynecology, Vol. 233, No. 1, 07.2025, p. e1-e5.

Research output: Contribution to journal › Article › peer-review

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Romero R, Conde-Agudelo A, da Fonseca E, O'Brien JM, Creasy GW, Hassan SS et al. Vaginal progesterone reduces the risk of preterm birth and adverse perinatal outcomes in singleton gestations with a midtrimester sonographic short cervix (≤25 mm): an updated individual patient data meta-analysis. American Journal of Obstetrics and Gynecology. 2025 Jul;233(1):e1-e5. doi: 10.1016/j.ajog.2025.03.013

Vaginal progesterone reduces the risk of preterm birth and adverse perinatal outcomes in singleton gestations with a midtrimester sonographic short cervix (≤25 mm): an updated individual patient data meta-analysis

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