TY - JOUR
T1 - Val153Met polymorphism of catechol-O-methyltransferase and prevalence of uterine leiomyomata
AU - Gooden, Kyna M.
AU - Schroeder, Jane C.
AU - North, Kari E.
AU - Gammon, Marilie D.
AU - Hartmann, Katherine E.
AU - Taylor, Jack
AU - Baird, Donna D.
PY - 2007/2
Y1 - 2007/2
N2 - The catechol-O-methyltransferase (COMT) gene encodes enzymes that inactivate catechol estrogens and may have a protective role in estrogen-induced tumorigenesis, such as uterine leiomyoma (fibroids). Val158Met is a common single-nucleotide polymorphism of the COMT gene (Ex4-12 G>A; rs4680) that results in a lower activity enzyme, increasing susceptibility to tumorigenesis. The purpose of this study was to evaluate the relation between the COMTVal158Met polymorphism and uterine fibroids. Participants were 972 premenopausal African American (n = 576) and white (n = 396) women from a cross-sectional sample of women in the National Institute of Environmental Health Science's Uterine Fibroid Study. Blood was collected from participants for DNA, and telephone interviews and questionnaires were completed to gather demographic and reproductive history. Prevalence ratios and 95% confidence intervals were estimated using race-specific log-risk regression models. Effect measure modification by age, body mass index, oral contraceptive use, full-term births, smoking, and alcohol use were also evaluated. Distributions of genotypes and fibroid prevalence varied by race. No associations between fibroids and Val158Met were observed among African American or white participants. This study suggests that variation in this polymorphism alone does not affect fibroid prevalence. Additional research is needed to examine other variations and haplotypes within the COMT gene.
AB - The catechol-O-methyltransferase (COMT) gene encodes enzymes that inactivate catechol estrogens and may have a protective role in estrogen-induced tumorigenesis, such as uterine leiomyoma (fibroids). Val158Met is a common single-nucleotide polymorphism of the COMT gene (Ex4-12 G>A; rs4680) that results in a lower activity enzyme, increasing susceptibility to tumorigenesis. The purpose of this study was to evaluate the relation between the COMTVal158Met polymorphism and uterine fibroids. Participants were 972 premenopausal African American (n = 576) and white (n = 396) women from a cross-sectional sample of women in the National Institute of Environmental Health Science's Uterine Fibroid Study. Blood was collected from participants for DNA, and telephone interviews and questionnaires were completed to gather demographic and reproductive history. Prevalence ratios and 95% confidence intervals were estimated using race-specific log-risk regression models. Effect measure modification by age, body mass index, oral contraceptive use, full-term births, smoking, and alcohol use were also evaluated. Distributions of genotypes and fibroid prevalence varied by race. No associations between fibroids and Val158Met were observed among African American or white participants. This study suggests that variation in this polymorphism alone does not affect fibroid prevalence. Additional research is needed to examine other variations and haplotypes within the COMT gene.
KW - Catechol-O-methyltransferase gene
KW - Females
KW - Genetic predisposition to disease
KW - Genetics
KW - Leiomyomata
KW - Polymorphism
KW - Uterine fibroids
KW - Uterine neoplasms
UR - http://www.scopus.com/inward/record.url?scp=34648831808&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34648831808&partnerID=8YFLogxK
U2 - 10.1177/1933719106298687
DO - 10.1177/1933719106298687
M3 - Article
C2 - 17636223
AN - SCOPUS:34648831808
SN - 1933-7191
VL - 14
SP - 117
EP - 120
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 2
ER -
