Abstract
This experiment was designed to validate a single-day Morris Water Maze procedure used to assess cognitive functioning in rats. Separate groups of randomly assigned rats received either bilateral or unilateral fimbria fomix transections, bilateral or unilateral cortical ablations, or a sham surgical control procedure. Subjects were tested 7 days postoperatively with a modified version of the Morris Water Maze procedure that requires only a single day of training. The results indicated that bilateral fimbria fornix transections severely disrupted acquisition. Unilateral fimbria fornix transections and bilateral and unilateral cortical lesions disrupted acquisition less severely bat impaired subsequent test performance. In general, unilateral lesions of both types produced less severe deficits than bilateral lesions. The practical and analytical advantages of the single-day procedure are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 17-22 |
| Number of pages | 6 |
| Journal | Brain Research Bulletin |
| Volume | 39 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1996 |
Bibliographical note
Funding Information:Portions of these results were presented at the annual meeting of the Midwestern Psychological Association, Chicago, IL, May, 1993. This research was supported by a Grant from the National Institute of Health (NS31220).
Funding
Portions of these results were presented at the annual meeting of the Midwestern Psychological Association, Chicago, IL, May, 1993. This research was supported by a Grant from the National Institute of Health (NS31220).
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | |
| National Institute of Neurological Disorders and Stroke | P01NS031220 |
Keywords
- Behavioral assessment
- Brain function
- Brain lesions
- Cognitive deficits
- Morris Water Maze
- Spatial learning
- Trauma
ASJC Scopus subject areas
- General Neuroscience