Validation of maternal recall of early pregnancy medication exposure using prospective diary data

Alexandra C. Sundermann, Katherine E. Hartmann, Sarah H. Jones, Eric S. Torstenson, Digna R. Velez Edwards

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Purpose Data about maternal recall accuracy for classifying early pregnancy medication exposure are meager. Nonetheless, studies often rely on recall to evaluate potential impact of pharmaceuticals on the developing fetus. Methods Right from the Start is a community-based pregnancy cohort that enrolled women from North Carolina, Tennessee, and Texas. A subset of 318 women participated in daily medication diaries initiated before conception (2006–2012). We examined nonsteroidal anti-inflammatory drugs (NSAIDs) as an example of a drug type that is difficult to study due to its intermittent and primarily over-the-counter use as well as its incomplete documentation in medical and pharmaceutical records. Selective serotonin reuptake inhibitors (SSRI) were assessed as a prescription medication comparator. Maternal recall of NSAID and SSRI use in early pregnancy was examined by comparing diary data (gold standard) to first-trimester interview. Results Sensitivity and specificity for recall of NSAID exposure were 78.6% and 62.3%, respectively (kappa statistic: 0.41), with 72.3% agreement for exposure classification. Sensitivity and specificity for recall of SSRI exposure were 77.8% and 99.0%, respectively (kappa statistic: 0.79), with 97.8% agreement. Conclusions Our findings suggest the validity of maternal recall varies with medication type and prospective data collection should be prioritized when studying early pregnancy drug exposures.

Original languageEnglish
Pages (from-to)135-139.e2
JournalAnnals of Epidemiology
Volume27
Issue number2
DOIs
StatePublished - Feb 1 2017

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

  • Diary
  • Mental recall
  • Nonsteroidal anti-inflammatory agents
  • Pregnancy
  • Serotonin and noradrenaline reuptake inhibitors
  • Validation studies

ASJC Scopus subject areas

  • Epidemiology

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