Validation of reported GLT6D1 (Rs1537415), IL10 (rs6667202), and ANRIL (rs1333048) single nucleotide polymorphisms for aggressive periodontitis in a Brazilian population

Tiago Taiete, Marcio Zaffalon Casati, Camila Schmidt Stolf, Mônica Grazieli Corrêa, Mauro Pedrine Santamaria, Naira Maria Rebelato Bechara Andere, Ricardo D. Coletta, Enilson Antonio Sallum, Francisco Humberto Nociti Júnior, Karina Gonzales Silvério, Renato Corrêa Viana Casarin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background: Aggressive periodontitis (AgP) is influenced by genetic factors. Recently, the single nucleotide polymorphisms (SNPs) rs1537415 (GLT6D1), rs6667202 (IL10), and rs1333048 (ANRIL) were associated with AgP in different European populations. However, these specific SNPs have not yet been determined in Brazilians. Therefore, this study investigated whether these SNPs previously associated with AgP could be replicated among Brazilians. Methods: The SNPs rs1537415, rs6667202, and rs1333048 were genotyped using 5′-nuclease allelic discrimination assay in AgP (n = 200), chronic periodontitis (CP, n = 190), and healthy patients (H, n = 196). Differences in allele and genotype frequencies were analyzed using chi-square tests and stepwise logistic regression. Results: The minor C allele of rs6667202 was less frequently detected in AgP patients (23.5%) when compared to non-AgP groups (H = 34.2% and CP = 30.3%; p < 0.01), making the SNP protective againstAgP occurrence. Moreover, the final logistic model for AgP diagnosis included gender (p = 0.001) and the SNP rs6667202 (p < 0.001) as significant variables. The SNPs rs1537415 and rs1333048 did not show associations with AgP. Conclusion: Only the SNP rs6667202 was associated with AgP in a Brazilian population, being the minor C allele protective against AgP. Moreover, SNPs rs1333048 and rs1537415, previously associated with AgP in other population, was not validated to Brazilian population.

Original languageEnglish
Pages (from-to)44-51
Number of pages8
JournalJournal of Periodontology
Volume90
Issue number1
DOIs
StatePublished - 2019

Bibliographical note

Publisher Copyright:
© 2018 American Academy of Periodontology.

Keywords

  • Alleles
  • Genetic markers
  • Genetic variation
  • Genotype
  • Periodontal diseases

ASJC Scopus subject areas

  • Periodontics

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