Validity of the semi-infinite tumor model in tissue optics: A Monte Carlo study

Caigang Zhu, Quan Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

A Monte Carlo code based on a public domain code, MCML, was developed for the simulation of light transport in layered tissue models with buried tumor-like targets. We used the code to investigate the validity of the semi-infinite tumor assumption in an epithelial tissue model. The epithelial tissue model consists of three layers, which includes the top epithelium, the middle tumor and the bottom stroma. Diffuse reflectance is simulated for a fiber-optic probe in commonly used configurations. It is demonstrated that the validity of the semifinite tumor layer model depends on the fiber-optic probe configuration and the tumor dimensions. The results of this study provide a guide in the selection of appropriate light transport models and fiber-optic probe configurations in the optical diagnosis of early epithelial cancers.

Original languageEnglish
Title of host publication2010 Photonics Global Conference, PGC 2010
DOIs
StatePublished - 2010
Event2010 Photonics Global Conference, PGC 2010 - Orchard, Singapore
Duration: Dec 14 2010Dec 16 2010

Publication series

Name2010 Photonics Global Conference, PGC 2010

Conference

Conference2010 Photonics Global Conference, PGC 2010
Country/TerritorySingapore
CityOrchard
Period12/14/1012/16/10

Keywords

  • Early cancer
  • Epithelial tissue
  • Monte Carlo
  • Semi-infinite tissue model

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mathematical Physics
  • Atomic and Molecular Physics, and Optics

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