TY - GEN
T1 - Validity of the semi-infinite tumor model in tissue optics
AU - Zhu, Caigang
AU - Liu, Quan
PY - 2010
Y1 - 2010
N2 - A Monte Carlo code based on a public domain code, MCML, was developed for the simulation of light transport in layered tissue models with buried tumor-like targets. We used the code to investigate the validity of the semi-infinite tumor assumption in an epithelial tissue model. The epithelial tissue model consists of three layers, which includes the top epithelium, the middle tumor and the bottom stroma. Diffuse reflectance is simulated for a fiber-optic probe in commonly used configurations. It is demonstrated that the validity of the semifinite tumor layer model depends on the fiber-optic probe configuration and the tumor dimensions. The results of this study provide a guide in the selection of appropriate light transport models and fiber-optic probe configurations in the optical diagnosis of early epithelial cancers.
AB - A Monte Carlo code based on a public domain code, MCML, was developed for the simulation of light transport in layered tissue models with buried tumor-like targets. We used the code to investigate the validity of the semi-infinite tumor assumption in an epithelial tissue model. The epithelial tissue model consists of three layers, which includes the top epithelium, the middle tumor and the bottom stroma. Diffuse reflectance is simulated for a fiber-optic probe in commonly used configurations. It is demonstrated that the validity of the semifinite tumor layer model depends on the fiber-optic probe configuration and the tumor dimensions. The results of this study provide a guide in the selection of appropriate light transport models and fiber-optic probe configurations in the optical diagnosis of early epithelial cancers.
KW - Early cancer
KW - Epithelial tissue
KW - Monte Carlo
KW - Semi-infinite tissue model
UR - http://www.scopus.com/inward/record.url?scp=79952348108&partnerID=8YFLogxK
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U2 - 10.1109/PGC.2010.5705954
DO - 10.1109/PGC.2010.5705954
M3 - Conference contribution
AN - SCOPUS:79952348108
SN - 9781424498826
T3 - 2010 Photonics Global Conference, PGC 2010
BT - 2010 Photonics Global Conference, PGC 2010
Y2 - 14 December 2010 through 16 December 2010
ER -