Validity of the semi-infinite tumor model in tissue optics: A Monte Carlo study

Caigang Zhu; Quan Liu

doi:10.1109/PGC.2010.5705954

Validity of the semi-infinite tumor model in tissue optics: A Monte Carlo study

Caigang Zhu
, Quan Liu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

5 Scopus citations

Abstract

A Monte Carlo code based on a public domain code, MCML, was developed for the simulation of light transport in layered tissue models with buried tumor-like targets. We used the code to investigate the validity of the semi-infinite tumor assumption in an epithelial tissue model. The epithelial tissue model consists of three layers, which includes the top epithelium, the middle tumor and the bottom stroma. Diffuse reflectance is simulated for a fiber-optic probe in commonly used configurations. It is demonstrated that the validity of the semifinite tumor layer model depends on the fiber-optic probe configuration and the tumor dimensions. The results of this study provide a guide in the selection of appropriate light transport models and fiber-optic probe configurations in the optical diagnosis of early epithelial cancers.

Original language	English
Title of host publication	2010 Photonics Global Conference, PGC 2010
DOIs	https://doi.org/10.1109/PGC.2010.5705954
State	Published - 2010
Event	2010 Photonics Global Conference, PGC 2010 - Orchard, Singapore Duration: Dec 14 2010 → Dec 16 2010

Publication series

Name	2010 Photonics Global Conference, PGC 2010

Conference

Conference	2010 Photonics Global Conference, PGC 2010
Country/Territory	Singapore
City	Orchard
Period	12/14/10 → 12/16/10

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Early cancer
Epithelial tissue
Monte Carlo
Semi-infinite tissue model

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Mathematical Physics
Atomic and Molecular Physics, and Optics

Access to Document

10.1109/PGC.2010.5705954

Cite this

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title = "Validity of the semi-infinite tumor model in tissue optics: A Monte Carlo study",

abstract = "A Monte Carlo code based on a public domain code, MCML, was developed for the simulation of light transport in layered tissue models with buried tumor-like targets. We used the code to investigate the validity of the semi-infinite tumor assumption in an epithelial tissue model. The epithelial tissue model consists of three layers, which includes the top epithelium, the middle tumor and the bottom stroma. Diffuse reflectance is simulated for a fiber-optic probe in commonly used configurations. It is demonstrated that the validity of the semifinite tumor layer model depends on the fiber-optic probe configuration and the tumor dimensions. The results of this study provide a guide in the selection of appropriate light transport models and fiber-optic probe configurations in the optical diagnosis of early epithelial cancers.",

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doi = "10.1109/PGC.2010.5705954",

language = "English",

isbn = "9781424498826",

series = "2010 Photonics Global Conference, PGC 2010",

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AU - Liu, Quan

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N2 - A Monte Carlo code based on a public domain code, MCML, was developed for the simulation of light transport in layered tissue models with buried tumor-like targets. We used the code to investigate the validity of the semi-infinite tumor assumption in an epithelial tissue model. The epithelial tissue model consists of three layers, which includes the top epithelium, the middle tumor and the bottom stroma. Diffuse reflectance is simulated for a fiber-optic probe in commonly used configurations. It is demonstrated that the validity of the semifinite tumor layer model depends on the fiber-optic probe configuration and the tumor dimensions. The results of this study provide a guide in the selection of appropriate light transport models and fiber-optic probe configurations in the optical diagnosis of early epithelial cancers.

AB - A Monte Carlo code based on a public domain code, MCML, was developed for the simulation of light transport in layered tissue models with buried tumor-like targets. We used the code to investigate the validity of the semi-infinite tumor assumption in an epithelial tissue model. The epithelial tissue model consists of three layers, which includes the top epithelium, the middle tumor and the bottom stroma. Diffuse reflectance is simulated for a fiber-optic probe in commonly used configurations. It is demonstrated that the validity of the semifinite tumor layer model depends on the fiber-optic probe configuration and the tumor dimensions. The results of this study provide a guide in the selection of appropriate light transport models and fiber-optic probe configurations in the optical diagnosis of early epithelial cancers.

KW - Early cancer

KW - Epithelial tissue

KW - Monte Carlo

KW - Semi-infinite tissue model

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DO - 10.1109/PGC.2010.5705954

M3 - Conference contribution

AN - SCOPUS:79952348108

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T3 - 2010 Photonics Global Conference, PGC 2010

BT - 2010 Photonics Global Conference, PGC 2010

Y2 - 14 December 2010 through 16 December 2010

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Validity of the semi-infinite tumor model in tissue optics: A Monte Carlo study

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

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