Vancomycin Area Under the Curve Dosing and Monitoring at an Academic Medical Center: Transition Strategies and Lessons Learned

Eric R. Gregory, Donna R. Burgess, Sarah E. Cotner, Jeremy D. VanHoose, Alexander H. Flannery, Brian Gardner, Elizabeth B. Autry, Derek W. Forster, David S. Burgess, Katie L. Wallace

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Due to the inconsistent correlation of vancomycin trough concentrations with 24-hour area under the curve (AUC) and a desire to reduce rates of vancomycin-associated acute kidney injury, an institutional guideline was implemented by the Antimicrobial Stewardship Team in September 2017 to monitor vancomycin using AUC. Three stages were utilized to organize the process: preparation, implementation, and evaluation. The preparation stage was used to present literature to key stakeholders, and pharmacy meetings focused on the development of a dosing and monitoring guideline. Along with institution-wide education, the implementation stage included information technology development and support. The evaluation stage was comprised of quality improvement and clinical research. Future plans include dissemination of the results and analyses. Numerous lessons were learned due to barriers experienced during the process, but the transition was successful.

Original languageEnglish
Pages (from-to)774-778
Number of pages5
JournalJournal of Pharmacy Practice
Volume33
Issue number6
DOIs
StatePublished - Dec 2020

Bibliographical note

Publisher Copyright:
© The Author(s) 2019.

Keywords

  • acute kidney injury
  • area under the curve
  • therapeutic drug monitoring
  • vancomycin

ASJC Scopus subject areas

  • Pharmacology (medical)

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