Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats

Megan M. Kangiser, Linda P. Dwoskin, Guangrong Zheng, Peter A. Crooks, Dustin J. Stairs

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Methamphetamine is a potent psychostimulant with high abuse rates. Currently, there is no Food and Drug Administration-approved pharmacotherapy for methamphetamine addiction. Ideally, a pharmacotherapy should selectively decrease methamphetamine self-administration without affecting responding for other reinforcers. One way to test this is with the use of a multiple schedule of reinforcement, in which drug and food are available in alternating components within a session. The present study evaluated GZ-793A, a vesicular monoamine transporter-2 inhibitor, and varenicline, a partial agonist at α4β2 and full agonist at α7 nicotinic acetylcholine receptors, for their ability to decrease methamphetamine and food self-administration using a multiple schedule of reinforcement. Male Sprague-Dawley rats self-administered methamphetamine (0.03 mg/kg/intravenous infusion) and food pellets under a multiple schedule of reinforcement. GZ-793A or varenicline was administered before multiple schedule sessions. GZ-793A (5 and 20 mg/kg) significantly decreased methamphetamine intake compared with saline and did not alter food-maintained responding. In contrast, varenicline decreased methamphetamine intake less specifically across time. The results suggest that vesicular monoamine transporter-2 inhibition may be a viable pharmacological target for the treatment of methamphetamine-use disorders.

Original languageEnglish
Pages (from-to)87-97
Number of pages11
JournalBehavioural Pharmacology
Issue number1
StatePublished - 2018

Bibliographical note

Funding Information:
Funding was kindly provided by the Creighton University College of Arts and Science, the Ferlic Summer Undergraduate Research Scholarship, and by an NIH grant DA013519.

Publisher Copyright:
© 2018 Wolters Kluwer Health, Inc.


  • GZ-793A
  • Methamphetamine
  • Multiple schedule
  • Rat
  • Self-administration
  • Varenicline

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


Dive into the research topics of 'Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats'. Together they form a unique fingerprint.

Cite this