Variance Control Procedures

Heidi L. Weiss, Jianrong Wu, Katrina Epnere, O. Dale Williams

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


This chapter covers the concepts of variance and sources of variation for clinical trial data. Common metrics to quantify the extent of variability in relation to the mean are introduced as are clinical trial design techniques and statistical analysis methods to control and reduce this variation. The uses of variance as a data quality assessment tool in large-scale, long-term multicenter clinical trials are highlighted.

Original languageEnglish
Title of host publicationPrinciples and Practice of Clinical Trials
Number of pages9
ISBN (Electronic)9783319526362
StatePublished - Jan 1 2022

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2022. All rights are reserved.


  • Analysis of covariance
  • Clinical trial
  • Coefficient of variation
  • Crossover design
  • Data quality assessment
  • Matched design
  • Measurement errors
  • Multiple regression analysis
  • Power
  • Random error
  • Repeated measures design
  • Sample size
  • Systematic errors
  • Technical error
  • Variance

ASJC Scopus subject areas

  • General Medicine
  • General Mathematics


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