Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels

doi:10.1186/s12864-016-2788-x

Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: CCL16 is a chemokine predominantly expressed in the liver, but is also found in the blood and brain, and is known to play important roles in immune response and angiogenesis. Little is known about the gene's regulation. Methods: Here, we test for potential causal SNPs that affect CCL16 protein levels in both blood plasma and cerebrospinal fluid in a genome-wide association study across two datasets. We then use METAL to performed meta-analyses with a significance threshold of p 5x10^-8. We removed SNPs where the direction of the effect was different between the two datasets. Results: We identify 10 SNPs associated with increased CCL16 protein levels in both biological fluids. Conclusions: Our results will help understand CCL16's regulation, allowing researchers to better understand the gene's effects on human health.

Original language	English
Article number	437
Journal	BMC Genomics
Volume	17
DOIs	https://doi.org/10.1186/s12864-016-2788-x
State	Published - Jun 29 2016

Bibliographical note

Publisher Copyright:
© 2016 The Author(s).

Funding

Publication for this article was funded by Brigham Young University’s Department of Biology. This article has been published as part of BMC Genomics Volume 17 Supplement 3, 2016: Selected articles from the 12th Annual Biotechnology and Bioinformatics Symposium: genomics. The full contents of the supplement are available online at https://bmcgenomics.biomedcentral.com/ articles/supplements/volume-17-supplement-3.

Funders	Funder number
Brigham Young University’s Department of Biology
UK Industrial Decarbonization Research and Innovation Centre
U.S. Department of Health & Human Services \| NIH \| National Institute on Aging (U.S. National Institute on Aging)	U24AG021886, U01AG024904, U01AG032984, R01AG033193, R01AG042611, U01AG016976, P50AG005681, P01AG003991, P01AG026276
National Heart, Lung, and Blood Institute (NHLBI)	R01HL105756
UK Medical Research Council, Engineering and Physical Sciences Research Council	G0300429, MR/L023784/1
Wellcome Trust	082604

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Association
Blood
Brain
CCL16
Cerebrospinal fluid
Genetics
Plasma

ASJC Scopus subject areas

Biotechnology
Genetics

Access to Document

10.1186/s12864-016-2788-x

Cite this

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title = "Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels",

abstract = "Background: CCL16 is a chemokine predominantly expressed in the liver, but is also found in the blood and brain, and is known to play important roles in immune response and angiogenesis. Little is known about the gene's regulation. Methods: Here, we test for potential causal SNPs that affect CCL16 protein levels in both blood plasma and cerebrospinal fluid in a genome-wide association study across two datasets. We then use METAL to performed meta-analyses with a significance threshold of p 5x10-8. We removed SNPs where the direction of the effect was different between the two datasets. Results: We identify 10 SNPs associated with increased CCL16 protein levels in both biological fluids. Conclusions: Our results will help understand CCL16's regulation, allowing researchers to better understand the gene's effects on human health.",

keywords = "Association, Blood, Brain, CCL16, Cerebrospinal fluid, Genetics, Plasma",

author = "Ebbert, \{Mark T.W.\} and Staley, \{Lyndsay A.\} and Joshua Parker and Sheradyn Parker and Matthew Bailey and Michael Weiner and Paul Aisen and Ronald Petersen and Jack, \{Clifford R.\} and William Jagust and Trojanowki, \{John Q.\} and Toga, \{Arthur W.\} and Laurel Beckett and Green, \{Robert C.\} and Saykin, \{Andrew J.\} and John Morris and Ridge, \{Perry G.\} and Goate, \{Alison M.\} and Kauwe, \{John S.K.\}",

note = "Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

month = jun,

day = "29",

doi = "10.1186/s12864-016-2788-x",

language = "English",

volume = "17",

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TY - JOUR

T1 - Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels

AU - Ebbert, Mark T.W.

AU - Staley, Lyndsay A.

AU - Parker, Joshua

AU - Parker, Sheradyn

AU - Bailey, Matthew

AU - Weiner, Michael

AU - Aisen, Paul

AU - Petersen, Ronald

AU - Jack, Clifford R.

AU - Jagust, William

AU - Trojanowki, John Q.

AU - Toga, Arthur W.

AU - Beckett, Laurel

AU - Green, Robert C.

AU - Saykin, Andrew J.

AU - Morris, John

AU - Ridge, Perry G.

AU - Goate, Alison M.

AU - Kauwe, John S.K.

PY - 2016/6/29

Y1 - 2016/6/29

N2 - Background: CCL16 is a chemokine predominantly expressed in the liver, but is also found in the blood and brain, and is known to play important roles in immune response and angiogenesis. Little is known about the gene's regulation. Methods: Here, we test for potential causal SNPs that affect CCL16 protein levels in both blood plasma and cerebrospinal fluid in a genome-wide association study across two datasets. We then use METAL to performed meta-analyses with a significance threshold of p 5x10-8. We removed SNPs where the direction of the effect was different between the two datasets. Results: We identify 10 SNPs associated with increased CCL16 protein levels in both biological fluids. Conclusions: Our results will help understand CCL16's regulation, allowing researchers to better understand the gene's effects on human health.

AB - Background: CCL16 is a chemokine predominantly expressed in the liver, but is also found in the blood and brain, and is known to play important roles in immune response and angiogenesis. Little is known about the gene's regulation. Methods: Here, we test for potential causal SNPs that affect CCL16 protein levels in both blood plasma and cerebrospinal fluid in a genome-wide association study across two datasets. We then use METAL to performed meta-analyses with a significance threshold of p 5x10-8. We removed SNPs where the direction of the effect was different between the two datasets. Results: We identify 10 SNPs associated with increased CCL16 protein levels in both biological fluids. Conclusions: Our results will help understand CCL16's regulation, allowing researchers to better understand the gene's effects on human health.

KW - Association

KW - Blood

KW - Brain

KW - CCL16

KW - Cerebrospinal fluid

KW - Genetics

KW - Plasma

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DO - 10.1186/s12864-016-2788-x

M3 - Article

C2 - 27357396

AN - SCOPUS:84976484009

SN - 1471-2164

VL - 17

JO - BMC Genomics

JF - BMC Genomics

M1 - 437

ER -

Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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