Verifast: An integrated system for flexible CTC isolation and analysis

Benjamin P. Casavant, Scott M. Berry, Joshua Lang, David J. Guckenberger, David J. Beebe

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Circulating tumor cells (CTCs) are rare cellular events that are relevant as a prognostic for many epithelial origin cancers. CTCs offer a unique insight into the metastatic cascade and are accessible by a simple blood draw. Here, we demonstrate a method for high efficiency and purity CTC isolation that leaves these cells accessible for downstream analysis in order to study this highly relevant tumor cell population for targets or responses to cancer therapies. We present the VerIFAST, a method and device incorporating all facets of CTC analysis from isolation to enumeration and intracellular staining.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Pages1393-1395
Number of pages3
StatePublished - 2012
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: Oct 28 2012Nov 1 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Conference

Conference16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Country/TerritoryJapan
CityOkinawa
Period10/28/1211/1/12

Keywords

  • Buffycoat
  • Cancer
  • Cell isolation
  • CTC
  • IFAST

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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