Admission-to-discharge temperature reduction in decompensated heart failure is associated with rehospitalization

Translated title of the contribution: Admission-to-discharge temperature reduction in decompensated heart failure is associated with rehospitalization

H. R. Omar, R. Charnigo, M. Guglin

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Introduction: Decreasing body temperature on first follow-up visit—relative to discharge—predicts early rehospitalization in heart failure (HF). We studied whether admission-to-discharge temperature reduction was associated with increased HF rehospitalization in the ESCAPE trial. Methods: We compared patients with or without ≥1 °C decrease in temperature from admission-to-discharge. The study endpoint was rehospitalization due to HF for up to 6 months after discharge. Results: Among 354 patients (average age 57 years, 73% men) with recorded admission and discharge temperature, 22 (6.2%) had an admission-to-discharge temperature reduction ≥1 ºC. Patients with admission-to-discharge temperature reduction ≥1 ºC had higher frequency of rehospitalization for HF (68.2% vs. 44.3%, estimated odds ratio [OR] 2.697, 95% confidence interval [CI] 1.072–6.787, P = 0.029) despite a significantly higher admission temperature. On multivariate analysis, admission-to-discharge temperature reduction ≥1 ºC predicted rehospitalization for HF (OR 2.02, 95% CI 1.028–3.966, P = 0.041) after adjustment for age, BMI, baseline Na, creatinine, ejection fraction and discharge NYHA class. A standard logistic model treating temperature change as a continuous variable, and a model using a restricted cubic spline, did not demonstrate a statistically significant relationship between temperature reduction and HF rehospitalization. Subsequently, an altered logistic model was fit expressing the log odds of HF rehospitalization as a piecewise linear function of temperature decrease; this model did demonstrate statistical significance (P = 0.013) with an estimated odds ratio of 1.140 per 0.1 ºC beyond 0.5 ºC. Conclusion: Admission-to-discharge temperature reduction ≥1 ºC is an unfavorable prognostic sign associated with future rehospitalization due to HF.

Translated title of the contributionAdmission-to-discharge temperature reduction in decompensated heart failure is associated with rehospitalization
Original languageEnglish
Pages (from-to)649-655
Number of pages7
JournalHerz
Volume43
Issue number7
DOIs
StatePublished - Nov 1 2018

Bibliographical note

Publisher Copyright:
© 2017, Springer Medizin Verlag GmbH.

Keywords

  • Heart failure
  • Hypothermia
  • Morbidity
  • Mortality
  • Rehospitalization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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