A critical step in the life cycle of a virus is spread to a new target cell, which generally involves the release of new viral particles from the infected cell which can then initiate infection in the next target cell. While cell-free viral particles released into the extracellular environment are necessary for long distance spread, there are disadvantages to this mechanism. These include the presence of immune system components, the low success rate of infection by single particles, and the relative fragility of viral particles in the environment. Several mechanisms of direct cell-to-cell spread have been reported for animal viruses which would avoid the issues associated with cell-free particles. A number of viruses can utilize several different mechanisms of direct cell-to-cell spread, but our understanding of the differential usage by these pathogens is modest. Although the mechanisms of cell-to-cell spread differ among viruses, there is a common exploitation of key pathways and components of the cellular cytoskeleton. Remarkably, some of the viral mechanisms of cell-to-cell spread are surprisingly similar to those used by bacteria. Here we summarize the current knowledge of the conventional and non-conventional mechanisms of viral spread, the common methods used to detect viral spread, and the impact that these mechanisms can have on viral pathogenesis.
|Title of host publication
|Virus Assembly and Exit Pathways
|Margaret Kielian, Thomas C. Mettenleiter, Marilyn J. Roossinck
|Number of pages
|Published - Jan 2020
|Advances in Virus Research
Bibliographical noteFunding Information:
This work was supported in part by NIH grants AI051517 and AI140758 to R.E.D. and Fondecyt Inicio grant 11180269 to N.C.M. Images were created using BioRender.com .
© 2020 Elsevier Inc.
- Cell-to-cell spread
ASJC Scopus subject areas
- Infectious Diseases