Viral entry mechanisms: The increasing diversity of paramyxovirus entry

Everett C. Smith, Andreea Popa, Andres Chang, Cyril Masante, Rebecca Ellis Dutch

Research output: Contribution to journalShort surveypeer-review

136 Scopus citations

Abstract

The paramyxovirus family contains established human pathogens such as the measles virus and human respiratory syncytial virus, as well as emerging pathogens including the Hendra and Nipah viruses and the recently identified human metapneumovirus. Two major envelope glycoproteins, the attachment protein and the fusion protein, promote the processes of viral attachment and virus-cell membrane fusion required for entry. Although common mechanisms of fusion protein proteolytic activation and the mechanism of membrane fusion promotion have been shown in recent years, considerable diversity exists in the family relating to receptor binding and the potential mechanisms of fusion triggering.

Original languageEnglish
Pages (from-to)7217-7227
Number of pages11
JournalFEBS Journal
Volume276
Issue number24
DOIs
StatePublished - Dec 2009

Keywords

  • Fusion proteins
  • Paramyxovirus
  • Receptor binding
  • Viral entry

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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