Vital exhaustion and sudden cardiac death in the Atherosclerosis Risk in Communities Study

Brittany M. Bogle, Nona Sotoodehnia, Anna M. Kucharska-Newton, Wayne D. Rosamond

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective Vital exhaustion (VE), a construct defined as lack of energy, increased fatigue and irritability, and feelings of demoralisation, has been associated with cardiovascular events. We sought to examine the relation between VE and sudden cardiac death (SCD) in the Atherosclerosis Risk in Communities (ARIC) Study. Methods The ARIC Study is a predominately biracial cohort of men and women, aged 45-64 at baseline, initiated in 1987 through random sampling in four US communities. VE was measured using the Maastricht questionnaire between 1990 and 1992 among 13 923 individuals. Cox proportional hazards models were used to examine the hazard of out-of-hospital SCD across tertiles of VE scores. Results Through 2012, 457 SCD cases, defined as a sudden pulseless condition presumed due to a ventricular tachyarrhythmia in a previously stable individual, were identified in ARIC by physician record review. Adjusting for age, sex and race/centre, participants in the highest VE tertile had an increased risk of SCD (HR 1.48, 95% CI 1.17 to 1.87), but these findings did not remain significant after adjustment for established cardiovascular disease risk factors (HR 0.94, 95% CI 0.73 to 1.20). Conclusions Among participants of the ARIC study, VE was not associated with an increased risk for SCD after adjustment for cardiovascular risk factors.

Original languageEnglish
Pages (from-to)423-429
Number of pages7
JournalHeart
Volume104
Issue number5
DOIs
StatePublished - Mar 2018

Bibliographical note

Publisher Copyright:
© Article author(s) 2018. All rights reserved.

Keywords

  • epidemiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Vital exhaustion and sudden cardiac death in the Atherosclerosis Risk in Communities Study'. Together they form a unique fingerprint.

Cite this