Abstract
Variation in blood lead concentration is caused by a complex interaction of environmental, social, nutritional, and genetic factors. We evaluated the association between blood lead concentration and a vitamin D receptor (VDR) gene polymorphism. Environmental samples and blood were analyzed for lead, nutritional and behavioral factors were assessed, and VDR-Fok1 genotype was determined in 245 children. We found a significant interaction between floor dust lead and genotype on blood lead concentration. For every 1 μg/ft2 increase in floor dust, children with VDR-FF genotype had a 1.1% increase in blood lead [95% confidence interval (CI), 0.69-1.5], VDR-Ff, 0.53% increase (95% CI, 0.1-0.92), and VDR-ff, 3.8% increase (95% CI, 1.2-6.3); however, at floor dust levels < 10 μg/ft2, children with VDR-ff had the lowest blood lead concentrations. These data suggest that VDR-Fok1 is an effect modifier of the relationship of floor dust lead exposure and blood lead concentration.
| Original language | English |
|---|---|
| Pages (from-to) | 1665-1669 |
| Number of pages | 5 |
| Journal | Environmental Health Perspectives |
| Volume | 111 |
| Issue number | 13 |
| DOIs | |
| State | Published - Oct 1 2003 |
Keywords
- Child
- Dust
- Environmental exposure
- Fok1
- Gene-environment
- Lead
- Lead poisoning
- VDR
- Vitamin D receptor
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
