TY - JOUR
T1 - Vitamin D receptor Fok1 polymorphism and blood lead concentration in children
AU - Haynes, Erin N.
AU - Kalkwarf, Heidi J.
AU - Hornung, Richard
AU - Wenstrup, Richard
AU - Dietrich, Kim
AU - Lanphear, Bruce P.
PY - 2003/10/1
Y1 - 2003/10/1
N2 - Variation in blood lead concentration is caused by a complex interaction of environmental, social, nutritional, and genetic factors. We evaluated the association between blood lead concentration and a vitamin D receptor (VDR) gene polymorphism. Environmental samples and blood were analyzed for lead, nutritional and behavioral factors were assessed, and VDR-Fok1 genotype was determined in 245 children. We found a significant interaction between floor dust lead and genotype on blood lead concentration. For every 1 μg/ft2 increase in floor dust, children with VDR-FF genotype had a 1.1% increase in blood lead [95% confidence interval (CI), 0.69-1.5], VDR-Ff, 0.53% increase (95% CI, 0.1-0.92), and VDR-ff, 3.8% increase (95% CI, 1.2-6.3); however, at floor dust levels < 10 μg/ft2, children with VDR-ff had the lowest blood lead concentrations. These data suggest that VDR-Fok1 is an effect modifier of the relationship of floor dust lead exposure and blood lead concentration.
AB - Variation in blood lead concentration is caused by a complex interaction of environmental, social, nutritional, and genetic factors. We evaluated the association between blood lead concentration and a vitamin D receptor (VDR) gene polymorphism. Environmental samples and blood were analyzed for lead, nutritional and behavioral factors were assessed, and VDR-Fok1 genotype was determined in 245 children. We found a significant interaction between floor dust lead and genotype on blood lead concentration. For every 1 μg/ft2 increase in floor dust, children with VDR-FF genotype had a 1.1% increase in blood lead [95% confidence interval (CI), 0.69-1.5], VDR-Ff, 0.53% increase (95% CI, 0.1-0.92), and VDR-ff, 3.8% increase (95% CI, 1.2-6.3); however, at floor dust levels < 10 μg/ft2, children with VDR-ff had the lowest blood lead concentrations. These data suggest that VDR-Fok1 is an effect modifier of the relationship of floor dust lead exposure and blood lead concentration.
KW - Child
KW - Dust
KW - Environmental exposure
KW - Fok1
KW - Gene-environment
KW - Lead
KW - Lead poisoning
KW - VDR
KW - Vitamin D receptor
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U2 - 10.1289/ehp.6167
DO - 10.1289/ehp.6167
M3 - Review article
C2 - 14527848
AN - SCOPUS:0142124275
SN - 0091-6765
VL - 111
SP - 1665
EP - 1669
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
IS - 13
ER -
