Vitamin E and neurodegenerative disorders associated with oxidative stress

D. Allan Butterfield, Alessandra Castegna, Jennifer Drake, Giovanni Scapagnini, Vittorio Calabrese

Research output: Contribution to journalReview articlepeer-review

141 Scopus citations


Several neurodegenerative disorders are associated with oxidative stress that is manifested by lipid peroxidation, protein oxidation and other markers. Included in these disorders in which oxidative stress is thought to play an important role in their pathogenesis are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), tardive dyskinesia, Huntington's disease (HD), and multiple sclerosis. This review presents some of the chemistry of vitamin E as an antioxidant and summarizes studies in which vitamin E has been employed in these disorders and models thereof.

Original languageEnglish
Pages (from-to)229-239
Number of pages11
JournalNutritional Neuroscience
Issue number4
StatePublished - 2002


  • Lipid peroxidation
  • Neurodegenerative disorders
  • Oxidative stress
  • Protein oxidation
  • Vitamin E

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • General Neuroscience
  • Nutrition and Dietetics


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