TY - JOUR
T1 - Vitamin E and neurodegenerative disorders associated with oxidative stress
AU - Butterfield, D. Allan
AU - Castegna, Alessandra
AU - Drake, Jennifer
AU - Scapagnini, Giovanni
AU - Calabrese, Vittorio
PY - 2002
Y1 - 2002
N2 - Several neurodegenerative disorders are associated with oxidative stress that is manifested by lipid peroxidation, protein oxidation and other markers. Included in these disorders in which oxidative stress is thought to play an important role in their pathogenesis are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), tardive dyskinesia, Huntington's disease (HD), and multiple sclerosis. This review presents some of the chemistry of vitamin E as an antioxidant and summarizes studies in which vitamin E has been employed in these disorders and models thereof.
AB - Several neurodegenerative disorders are associated with oxidative stress that is manifested by lipid peroxidation, protein oxidation and other markers. Included in these disorders in which oxidative stress is thought to play an important role in their pathogenesis are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), tardive dyskinesia, Huntington's disease (HD), and multiple sclerosis. This review presents some of the chemistry of vitamin E as an antioxidant and summarizes studies in which vitamin E has been employed in these disorders and models thereof.
KW - Lipid peroxidation
KW - Neurodegenerative disorders
KW - Oxidative stress
KW - Protein oxidation
KW - Vitamin E
UR - https://www.scopus.com/pages/publications/0035988588
UR - https://www.scopus.com/pages/publications/0035988588#tab=citedBy
U2 - 10.1080/10284150290028954
DO - 10.1080/10284150290028954
M3 - Review article
C2 - 12168685
AN - SCOPUS:0035988588
SN - 1028-415X
VL - 5
SP - 229
EP - 239
JO - Nutritional Neuroscience
JF - Nutritional Neuroscience
IS - 4
ER -