TY - JOUR
T1 - Vocal fold augmentation with calcium hydroxylapatite (CaHA)
AU - Rosen, Clark A.
AU - Gartner-Schmidt, Jackie
AU - Casiano, Roy
AU - Anderson, Timothy D.
AU - Johnson, Felicia
AU - Reussner, Lee
AU - Remacle, Marc
AU - Sataloff, Robert T.
AU - Abitbol, Jean
AU - Shaw, Gary
AU - Archer, Sanford
AU - McWhorter, Andrew
PY - 2007/2
Y1 - 2007/2
N2 - Objectives: Evaluate the effectiveness of CaHA injection for patients with glottal incompetence. Methods: Multi-center, open-label, prospective clinical study with each patient serving as his/her own control. Voice-related outcome measures were collected for pre-injection and 1, 3, and 6 months. Results: Sixty-eight patients were available for evaluation. Fifty percent of the injection procedures were done in office. Fifty-seven percent were diagnosed with unilateral paralysis and 42% with glottal incompetence with mobile vocal folds. Patient satisfaction 6 months post showed 56% had significantly improved voice and 38% reported moderately improved voice. Paired t tests from baseline to 6 months showed significant improvements on the VHI and VAS (vocal effort), CAPE-V judgments of voice severity and videoendostroboscopy ratings of glottal closure, and objective voice measures of glottal closure (MPT and S:Z ratio). Conclusions: Preliminary results in this large cohort of patients demonstrate excellent clinical results.
AB - Objectives: Evaluate the effectiveness of CaHA injection for patients with glottal incompetence. Methods: Multi-center, open-label, prospective clinical study with each patient serving as his/her own control. Voice-related outcome measures were collected for pre-injection and 1, 3, and 6 months. Results: Sixty-eight patients were available for evaluation. Fifty percent of the injection procedures were done in office. Fifty-seven percent were diagnosed with unilateral paralysis and 42% with glottal incompetence with mobile vocal folds. Patient satisfaction 6 months post showed 56% had significantly improved voice and 38% reported moderately improved voice. Paired t tests from baseline to 6 months showed significant improvements on the VHI and VAS (vocal effort), CAPE-V judgments of voice severity and videoendostroboscopy ratings of glottal closure, and objective voice measures of glottal closure (MPT and S:Z ratio). Conclusions: Preliminary results in this large cohort of patients demonstrate excellent clinical results.
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U2 - 10.1016/j.otohns.2006.07.014
DO - 10.1016/j.otohns.2006.07.014
M3 - Article
C2 - 17275539
AN - SCOPUS:33846698539
SN - 0194-5998
VL - 136
SP - 198.e1-198.e12
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 2
ER -