Vocal fold augmentation with calcium hydroxylapatite (CaHA)

Clark A. Rosen, Jackie Gartner-Schmidt, Roy Casiano, Timothy D. Anderson, Felicia Johnson, Lee Reussner, Marc Remacle, Robert T. Sataloff, Jean Abitbol, Gary Shaw, Sanford Archer, Andrew McWhorter

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Objectives: Evaluate the effectiveness of CaHA injection for patients with glottal incompetence. Methods: Multi-center, open-label, prospective clinical study with each patient serving as his/her own control. Voice-related outcome measures were collected for pre-injection and 1, 3, and 6 months. Results: Sixty-eight patients were available for evaluation. Fifty percent of the injection procedures were done in office. Fifty-seven percent were diagnosed with unilateral paralysis and 42% with glottal incompetence with mobile vocal folds. Patient satisfaction 6 months post showed 56% had significantly improved voice and 38% reported moderately improved voice. Paired t tests from baseline to 6 months showed significant improvements on the VHI and VAS (vocal effort), CAPE-V judgments of voice severity and videoendostroboscopy ratings of glottal closure, and objective voice measures of glottal closure (MPT and S:Z ratio). Conclusions: Preliminary results in this large cohort of patients demonstrate excellent clinical results.

Original languageEnglish
Pages (from-to)198.e1-198.e12
JournalOtolaryngology - Head and Neck Surgery
Issue number2
StatePublished - Feb 2007

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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