Vocal fold augmentation with calcium hydroxylapatite: Twelve-month report

Clark A. Rosen, Jackie Gartner-Schmidt, Roy Casiano, Timothy D. Anderson, Felicia Johnson, Marc Remacle, Robert T. Sataloff, Jean Abitbol, Gary Shaw, Sanford Archer, Richard I. Zraick

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


Objectives: To evaluate the long-term effectiveness of calcium hydroxylapatite (CaHA) vocal fold injection for patients with glottal insufficiency. Study Design: Multicenter, open-label, prospective clinical study of CaHA vocal fold injection. Methods: Each patient served as his/her own control. Voice-related outcome measures were collected for pre-injection, 1, 3, 6, and 12 months. Results: Sixty-three patients were available for evaluation. Fifty-three percent of the injection procedures were done in the office. Fifty-seven percent of patients were diagnosed with unilateral paralysis and 43% with glottal incompetence with mobile vocal folds. Patient satisfaction 12 months after injection showed 67% reporting a significant improvement in voice and 81% reporting at least a moderate improvement in voice. Utilizing the Voice Handicap Index-10, visual analog scale (vocal effort), Consensus Assessment Perceptual Evaluation V (judgments of voice severity), and objective voice measures of glottal closure (maximum phonation time and S:Z ratio), paired t tests showed significant improvements after treatment. A 22% further treatment rate was found at the 12-month time point. Conclusions: One-year results in this large cohort of patients with glottal incompetence treated with CaHA vocal fold injection demonstrate that excellent clinical results were achieved.

Original languageEnglish
Pages (from-to)1033-1041
Number of pages9
Issue number5
StatePublished - May 2009


  • General otolaryngology
  • Head and neck
  • Quality of life
  • Voice

ASJC Scopus subject areas

  • Otorhinolaryngology


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