Vochysiamides A and B: Two new bioactive carboxamides produced by the new species Diaporthe vochysiae

Sandriele Aparecida Noriler, Daiani Cristina Savi, Larissa V. Ponomareva, Renata Rodrigues, Jürgen Rohr, J. S. Thorson, Chirlei Glienke, Khaled A. Shaaban

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Endophytic fungi have been considered a rich source for bioactive secondary metabolites with novel chemical structures. A high diverse group of endophytes, isolated from different medicinal plants, belongs to the genus Diaporthe. In a previously study performed by our group the crude extract of strain LGMF1583 showed considerable antibacterial activity mainly against Gram-negative bacteria. Based on ITS phylogeny analysis, strain LGMF1583 was identified as belonging to Diaporthe genus and may represent a new species. In the present study, we described the new species Diporthe vochysiae based on multilocus phylogeny analysis and morphological characteristics. The species name refers to the host, from which strain LGMF1583 was isolated, the medicinal plant Vochysia divergens. In view of the biotechnological potential of strain LGMF1583, we have also characterized the secondary metabolites produced by D. vochysiae. Chemical assessment of the D. vochysiae LGMF1583 revealed two new carboxamides, vochysiamides A (1) and B (2), in addition to the known metabolite, 2,5-dihydroxybenzyl alcohol (3). In the biological activity analysis, vochysiamide B (2) displayed considerable antibacterial activity against the Gram-negative bacterium Klebsiella pneumoniae (KPC), a producer of carbapenemases, MIC of 80 μg/mL. Carbapenemases are considered a major antimicrobial resistance threat, and infections caused by KPC have been considered a public health problem worldwide, and new compounds with activity against this bacterium are nowadays even more required.

Original languageEnglish
Article number104273
JournalFitoterapia
Volume138
DOIs
StatePublished - Oct 2019

Bibliographical note

Publisher Copyright:
© 2019

Keywords

  • Carbapenemases
  • Diaporthe genus
  • Medicinal plants
  • Secondary metabolites
  • Vochysia divergens

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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