Von Willebrand disease in China

Yingchun Wang, Zhenyu Li, Jianming Gu, Changgeng Ruan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Purpose To review the molecular pathogenesis in Chinese patients with von Willebrand disease (vWD) and polymorphisms of von Willebrand factor (vWF) in Chinese population. Data sources Both Chinese and English language literature search using MEDLINE (1985-1998), and original articles published in main Chinese and international journals. Study selection and data extraction After reviewing of the literature, 19 articles of them were selected that specifically addressed the stated purpose. Results The molecular pathogenesis of vWD was variant. Six cases of point mutation have been found in Chinese patients with vWD. The system of site-directed mutagenesis and expression of vWF gene was constructed. The polymorphisms of vWF gene are very different between Chinese and Gaucasians. Conclusion Combining to gene mutant in vWD patients, the use of site-directed mutagenesis and expression of vWF will help to understand the vWF function. The polymorphisms of vWF gene are useful marker in Chinese for carrier detection and prenatal diagnosis of vWD.

Original languageEnglish
Pages (from-to)677-680
Number of pages4
JournalChinese Medical Journal
Issue number8
StatePublished - Aug 2000


  • Chinese population
  • Point mutation polymorphism
  • Von Willebrand disease
  • Von Willebrand factor
  • Von Willebrand factor gene

ASJC Scopus subject areas

  • Medicine (all)


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