Watching the watcher: Regulation of p53 by mitochondria

Aaron K. Holley, Daret K. St. Clair

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations

Abstract

p53 has been referred to as the 'guardian of the genome' because of its role in protecting the cell from DNA damage. p53 performs its duties by regulating cell-cycle progression and DNA repair and, in cases of irreparable DNA damage' by executing programmed cell death. Mitochondria are an important target of transcription-dependent and -independent actions of p53 to carry out the apoptotic function. However, increasing evidence suggests that p53 activity is regulated by mitochondria. Cellular insults that alter mitochondrial function can consequences on p53 activity. In light of these new findings, the have important following review focuses on p53/mitochondria connections, in particular how redctive oxygen species generated at mitochondria regulate p53 activity. A better understanding of the mechanisms by which mitochondria regulate p53 may have an impact on our understanding of the development and progression of many diseases, especially cancer.

Original languageEnglish
Pages (from-to)117-130
Number of pages14
JournalFuture Oncology
Volume5
Issue number1
DOIs
StatePublished - 2009

Keywords

  • Mitochondria
  • P53
  • Reactive oxygen species
  • Skin cancer
  • Ultraviolet radiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Watching the watcher: Regulation of p53 by mitochondria'. Together they form a unique fingerprint.

Cite this