TY - JOUR
T1 - Weeding out bad waves
T2 - Towards selective cannabinoid circuit control in epilepsy
AU - Soltesz, Ivan
AU - Alger, Bradley E.
AU - Kano, Masanobu
AU - Lee, Sang Hun
AU - Lovinger, David M.
AU - Ohno-Shosaku, Takako
AU - Watanabe, Masahiko
N1 - Publisher Copyright:
© 2015 Macmillan Publishers Limited. All rights reserved.
PY - 2015/4/20
Y1 - 2015/4/20
N2 - Endocannabinoids are lipid-derived messengers, and both their synthesis and breakdown are under tight spatiotemporal regulation. As retrograde signalling molecules, endocannabinoids are synthesized postsynaptically but activate presynaptic cannabinoid receptor 1 (CB1) receptors to inhibit neurotransmitter release. In turn, CB1-expressing inhibitory and excitatory synapses act as strategically placed control points for activity-dependent regulation of dynamically changing normal and pathological oscillatory network activity. Here, we highlight emerging principles of cannabinoid circuit control and plasticity, and discuss their relevance for epilepsy and related comorbidities. New insights into cannabinoid signalling may facilitate the translation of the recent interest in cannabis-related substances as antiseizure medications to evidence-based treatment strategies.
AB - Endocannabinoids are lipid-derived messengers, and both their synthesis and breakdown are under tight spatiotemporal regulation. As retrograde signalling molecules, endocannabinoids are synthesized postsynaptically but activate presynaptic cannabinoid receptor 1 (CB1) receptors to inhibit neurotransmitter release. In turn, CB1-expressing inhibitory and excitatory synapses act as strategically placed control points for activity-dependent regulation of dynamically changing normal and pathological oscillatory network activity. Here, we highlight emerging principles of cannabinoid circuit control and plasticity, and discuss their relevance for epilepsy and related comorbidities. New insights into cannabinoid signalling may facilitate the translation of the recent interest in cannabis-related substances as antiseizure medications to evidence-based treatment strategies.
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U2 - 10.1038/nrn3937
DO - 10.1038/nrn3937
M3 - Review article
C2 - 25891509
AN - SCOPUS:84928104306
SN - 1471-003X
VL - 16
SP - 264
EP - 277
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 5
ER -