TY - JOUR
T1 - Wegener's granulomatosis in a pediatric patient
AU - Hayes, Don
AU - Iocono, Joseph A.
AU - Bennett, Jeffery S.
AU - Lachman, David Corey
AU - Ballard, Hubert O.
PY - 2003/12
Y1 - 2003/12
N2 - Wegener's Granulomatosis (WG) is characterized by the clinical triad of upper and lower respiratory disease and renal insufficiency. Because WG masquerades as a syndrome its diagnosis is often delayed. Astute clinicians should include WG in their differential diagnosis when a patient presents with these classic findings. The diagnosis is a clinicopathologic one made by biopsy of appropriate tissue showing necrotizing granulomatous vasculitis. Lung tissue obtained by open thoracotomy has the highest diagnostic yield. At one time a universally fatal illness WG is now treatable with cyclophosphamide and prednisone therapy with remission in most cases. The authors present a case report of a pediatric patient who was eventually diagnosed with WG. The case serves as a reminder to all clinicians to keep this entity as a part of their diagnostic armamentarium.
AB - Wegener's Granulomatosis (WG) is characterized by the clinical triad of upper and lower respiratory disease and renal insufficiency. Because WG masquerades as a syndrome its diagnosis is often delayed. Astute clinicians should include WG in their differential diagnosis when a patient presents with these classic findings. The diagnosis is a clinicopathologic one made by biopsy of appropriate tissue showing necrotizing granulomatous vasculitis. Lung tissue obtained by open thoracotomy has the highest diagnostic yield. At one time a universally fatal illness WG is now treatable with cyclophosphamide and prednisone therapy with remission in most cases. The authors present a case report of a pediatric patient who was eventually diagnosed with WG. The case serves as a reminder to all clinicians to keep this entity as a part of their diagnostic armamentarium.
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U2 - 10.1016/j.amjoto.2009.05.001
DO - 10.1016/j.amjoto.2009.05.001
M3 - Article
C2 - 14965025
AN - SCOPUS:1542611321
SN - 0030-1876
VL - 96
SP - 563
EP - 565
JO - The Journal of the Oklahoma State Medical Association
JF - The Journal of the Oklahoma State Medical Association
IS - 12
ER -