Abstract
Recent therapeutic advances provide heightened motivation for accurate diagnosis of the underlying biologic causes of dementia. This review focuses on the importance of clinical recognition of limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE affects approximately one-quarter of older adults and produces an amnestic syndrome that is commonly mistaken for Alzheimer's disease (AD). Although AD and LATE often co-occur in the same patients, these diseases differ in the protein aggregates driving neuropathology (Aβ amyloid/tau vs TDP-43). This review discusses signs and symptoms, relevant diagnostic testing, and potential treatment implications for LATE that may be helpful for physicians, patients, and families. ANN NEUROL 2023;94:211–222.
| Original language | English |
|---|---|
| Pages (from-to) | 211-222 |
| Number of pages | 12 |
| Journal | Annals of Neurology |
| Volume | 94 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 2023 |
Bibliographical note
Publisher Copyright:© 2023 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
Funding
The authors sincerely thank patients and colleagues who enabled this work. Funding was from NIH/NIA grants R01 AG061111 (G.A.J. and P.T.N.), P30 AG072946 (G.A.J. and P.T.N.), RF1 NS118584 (P.T.N.), F30 AG074524 (M.T.D.), P30 AG072975 (J.A.S.), R01 AG067482 (J.A.S.), UF1 NS100599 (K.A. and J.A.S.), R01 AG064233 (K.A. and J.A.S.), P30 AG072979 (D.A.W.), RF1 AG069474 (D.A.W.), and R01 AG072796 (D.A.W.). Thanks to Dr. Karin Nelson for editorial review and suggestions.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | |
| National Institute on Aging | P30 AG072975, R01 AG064233, UF1 NS100599, RF1 NS118584, R01 AG067482, RF1 AG069474, F30 AG074524, P30 AG072946, P30 AG072979, R01 AG061111, R01 AG072796 |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology